Email this article Telomere Length of Individual Chromosomes in Patients with Rheumatoid Arthritis
- Authors: Blinova E.A.1, Zinnatova E.V.2, Barkovskaya M.S.2, Borisov V.I.2, Sizikov A.E.2, Kozhevnikov V.S.2, Rubtsov N.B.1, Kozlov V.A.2
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Affiliations:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Research Institute of Fundamental and Clinical Immunology
- Issue: Vol 160, No 6 (2016)
- Pages: 779-782
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236939
- DOI: https://doi.org/10.1007/s10517-016-3308-3
- ID: 236939
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Abstract
We analyzed telomere length of individual chromosomes in peripheral blood lymphocytes of healthy individuals and patients with rheumatoid arthritis. Quantitative fluorescent in situ hybridization and subsequent computer analysis of metaphase chromosomes showed that distribution of telomere length on individual chromosomes is different under normal and pathological conditions. Patients with rheumatoid arthritis had significantly shorter chromosome 4p telomeres, which can be essential for pathogenesis of this multifactorial disease. Additionally, disease activity inversely correlated with telomere length on chromosome 10p carrying genes involved in T cell differentiation and proliferation.
About the authors
E. A. Blinova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: blinovaelena-85@yandex.ru
Russian Federation, Novosibirsk
E. V. Zinnatova
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Russian Federation, Novosibirsk
M. Sh. Barkovskaya
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Russian Federation, Novosibirsk
V. I. Borisov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Russian Federation, Novosibirsk
A. E. Sizikov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Russian Federation, Novosibirsk
V. S. Kozhevnikov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Russian Federation, Novosibirsk
N. B. Rubtsov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: blinovaelena-85@yandex.ru
Russian Federation, Novosibirsk
V. A. Kozlov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Russian Federation, Novosibirsk
