Telomere Length of Individual Chromosomes in Patients with Rheumatoid Arthritis
- Autores: Blinova E.1, Zinnatova E.2, Barkovskaya M.2, Borisov V.2, Sizikov A.2, Kozhevnikov V.2, Rubtsov N.1, Kozlov V.2
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Afiliações:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Research Institute of Fundamental and Clinical Immunology
- Edição: Volume 160, Nº 6 (2016)
- Páginas: 779-782
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236939
- DOI: https://doi.org/10.1007/s10517-016-3308-3
- ID: 236939
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Resumo
We analyzed telomere length of individual chromosomes in peripheral blood lymphocytes of healthy individuals and patients with rheumatoid arthritis. Quantitative fluorescent in situ hybridization and subsequent computer analysis of metaphase chromosomes showed that distribution of telomere length on individual chromosomes is different under normal and pathological conditions. Patients with rheumatoid arthritis had significantly shorter chromosome 4p telomeres, which can be essential for pathogenesis of this multifactorial disease. Additionally, disease activity inversely correlated with telomere length on chromosome 10p carrying genes involved in T cell differentiation and proliferation.
Sobre autores
E. Blinova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: blinovaelena-85@yandex.ru
Rússia, Novosibirsk
E. Zinnatova
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Rússia, Novosibirsk
M. Barkovskaya
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Rússia, Novosibirsk
V. Borisov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Rússia, Novosibirsk
A. Sizikov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Rússia, Novosibirsk
V. Kozhevnikov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Rússia, Novosibirsk
N. Rubtsov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: blinovaelena-85@yandex.ru
Rússia, Novosibirsk
V. Kozlov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Rússia, Novosibirsk
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