Telomere Length of Individual Chromosomes in Patients with Rheumatoid Arthritis
- Авторы: Blinova E.1, Zinnatova E.2, Barkovskaya M.2, Borisov V.2, Sizikov A.2, Kozhevnikov V.2, Rubtsov N.1, Kozlov V.2
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Учреждения:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Research Institute of Fundamental and Clinical Immunology
- Выпуск: Том 160, № 6 (2016)
- Страницы: 779-782
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236939
- DOI: https://doi.org/10.1007/s10517-016-3308-3
- ID: 236939
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Аннотация
We analyzed telomere length of individual chromosomes in peripheral blood lymphocytes of healthy individuals and patients with rheumatoid arthritis. Quantitative fluorescent in situ hybridization and subsequent computer analysis of metaphase chromosomes showed that distribution of telomere length on individual chromosomes is different under normal and pathological conditions. Patients with rheumatoid arthritis had significantly shorter chromosome 4p telomeres, which can be essential for pathogenesis of this multifactorial disease. Additionally, disease activity inversely correlated with telomere length on chromosome 10p carrying genes involved in T cell differentiation and proliferation.
Об авторах
E. Blinova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Автор, ответственный за переписку.
Email: blinovaelena-85@yandex.ru
Россия, Novosibirsk
E. Zinnatova
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Россия, Novosibirsk
M. Barkovskaya
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Россия, Novosibirsk
V. Borisov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Россия, Novosibirsk
A. Sizikov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Россия, Novosibirsk
V. Kozhevnikov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Россия, Novosibirsk
N. Rubtsov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: blinovaelena-85@yandex.ru
Россия, Novosibirsk
V. Kozlov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
Россия, Novosibirsk
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