Telomere Length of Individual Chromosomes in Patients with Rheumatoid Arthritis
- 作者: Blinova E.1, Zinnatova E.2, Barkovskaya M.2, Borisov V.2, Sizikov A.2, Kozhevnikov V.2, Rubtsov N.1, Kozlov V.2
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隶属关系:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Research Institute of Fundamental and Clinical Immunology
- 期: 卷 160, 编号 6 (2016)
- 页面: 779-782
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236939
- DOI: https://doi.org/10.1007/s10517-016-3308-3
- ID: 236939
如何引用文章
详细
We analyzed telomere length of individual chromosomes in peripheral blood lymphocytes of healthy individuals and patients with rheumatoid arthritis. Quantitative fluorescent in situ hybridization and subsequent computer analysis of metaphase chromosomes showed that distribution of telomere length on individual chromosomes is different under normal and pathological conditions. Patients with rheumatoid arthritis had significantly shorter chromosome 4p telomeres, which can be essential for pathogenesis of this multifactorial disease. Additionally, disease activity inversely correlated with telomere length on chromosome 10p carrying genes involved in T cell differentiation and proliferation.
作者简介
E. Blinova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: blinovaelena-85@yandex.ru
俄罗斯联邦, Novosibirsk
E. Zinnatova
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
俄罗斯联邦, Novosibirsk
M. Barkovskaya
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
俄罗斯联邦, Novosibirsk
V. Borisov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
俄罗斯联邦, Novosibirsk
A. Sizikov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
俄罗斯联邦, Novosibirsk
V. Kozhevnikov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
俄罗斯联邦, Novosibirsk
N. Rubtsov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: blinovaelena-85@yandex.ru
俄罗斯联邦, Novosibirsk
V. Kozlov
Research Institute of Fundamental and Clinical Immunology
Email: blinovaelena-85@yandex.ru
俄罗斯联邦, Novosibirsk
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