Email this article Cardiomyocyte Autophagia and Morphological Alterations in the Left Ventricular Myocardium during Acute Focal Ischemia
- Authors: Blagonravov M.L.1, Korshunova A.Y.1, Azova M.M.2, Bondar’ S.A.1, Frolov V.A.1
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Affiliations:
- Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship
- Department of Biology and General Genetics, Medical Institute of Russian University of People Friendship
- Issue: Vol 160, No 3 (2016)
- Pages: 398-400
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236716
- DOI: https://doi.org/10.1007/s10517-016-3180-1
- ID: 236716
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Abstract
In experiments on rabbits we evaluated the intensity of cardiomyocyte autophagia by the level beclin-1 protein and morphology of the left ventricular myocardium on days 1, 3, and 5 after the onset of focal ischemia caused by ligation of the descending branch of the left coronary artery. The morphological alterations in the left ventricular myocardium were accompanied by intensification of cardiomyocyte autophagia, which attained maximum on postligation day 1.
About the authors
M. L. Blagonravov
Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship
Author for correspondence.
Email: blagonravovm@mail.ru
Russian Federation, Moscow
A. Yu. Korshunova
Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship
Email: blagonravovm@mail.ru
Russian Federation, Moscow
M. M. Azova
Department of Biology and General Genetics, Medical Institute of Russian University of People Friendship
Email: blagonravovm@mail.ru
Russian Federation, Moscow
S. A. Bondar’
Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship
Email: blagonravovm@mail.ru
Russian Federation, Moscow
V. A. Frolov
Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship
Email: blagonravovm@mail.ru
Russian Federation, Moscow
