Cardiomyocyte Autophagia and Morphological Alterations in the Left Ventricular Myocardium during Acute Focal Ischemia


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In experiments on rabbits we evaluated the intensity of cardiomyocyte autophagia by the level beclin-1 protein and morphology of the left ventricular myocardium on days 1, 3, and 5 after the onset of focal ischemia caused by ligation of the descending branch of the left coronary artery. The morphological alterations in the left ventricular myocardium were accompanied by intensification of cardiomyocyte autophagia, which attained maximum on postligation day 1.

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M. Blagonravov

Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship

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Email: blagonravovm@mail.ru
俄罗斯联邦, Moscow

A. Korshunova

Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship

Email: blagonravovm@mail.ru
俄罗斯联邦, Moscow

M. Azova

Department of Biology and General Genetics, Medical Institute of Russian University of People Friendship

Email: blagonravovm@mail.ru
俄罗斯联邦, Moscow

S. Bondar’

Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship

Email: blagonravovm@mail.ru
俄罗斯联邦, Moscow

V. Frolov

Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship

Email: blagonravovm@mail.ru
俄罗斯联邦, Moscow


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