Cardiomyocyte Autophagia and Morphological Alterations in the Left Ventricular Myocardium during Acute Focal Ischemia


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Resumo

In experiments on rabbits we evaluated the intensity of cardiomyocyte autophagia by the level beclin-1 protein and morphology of the left ventricular myocardium on days 1, 3, and 5 after the onset of focal ischemia caused by ligation of the descending branch of the left coronary artery. The morphological alterations in the left ventricular myocardium were accompanied by intensification of cardiomyocyte autophagia, which attained maximum on postligation day 1.

Sobre autores

M. Blagonravov

Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship

Autor responsável pela correspondência
Email: blagonravovm@mail.ru
Rússia, Moscow

A. Korshunova

Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship

Email: blagonravovm@mail.ru
Rússia, Moscow

M. Azova

Department of Biology and General Genetics, Medical Institute of Russian University of People Friendship

Email: blagonravovm@mail.ru
Rússia, Moscow

S. Bondar’

Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship

Email: blagonravovm@mail.ru
Rússia, Moscow

V. Frolov

Department of General Pathology and Pathological Physiology, Medical Institute of Russian University of People Friendship

Email: blagonravovm@mail.ru
Rússia, Moscow


Declaração de direitos autorais © Springer Science+Business Media New York, 2016

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