Email this article Antitumor Properties of Modified Detonation Nanodiamonds and Sorbed Doxorubicin on the Model of Ehrlich Ascites Carcinoma
- Authors: Medvedeva N.N.1, Zhukov E.L.1, Inzhevatkin E.V.1,2, Bezzabotnov V.E.1
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Affiliations:
- V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
- Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 160, No 3 (2016)
- Pages: 372-375
- Section: Nanobiotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/236710
- DOI: https://doi.org/10.1007/s10517-016-3174-z
- ID: 236710
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Abstract
We studied antitumor properties of modified detonation nanodiamonds loaded with doxorubicin on in vivo model of Ehrlich ascites carcinoma. The type of tumor development and morphological characteristics of the liver, kidneys, and spleen were evaluated in experimental animals. Modified nanodiamonds injected intraperitoneally produced no antitumor effect on Ehrlich carcinoma. However, doxorubicin did not lose antitumor activity after sorption on modified nanodiamonds.
About the authors
N. N. Medvedeva
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: evgen_patolog@mail.ru
Russian Federation, Krasnoyarsk
E. L. Zhukov
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: evgen_patolog@mail.ru
Russian Federation, Krasnoyarsk
E. V. Inzhevatkin
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation; Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences
Email: evgen_patolog@mail.ru
Russian Federation, Krasnoyarsk; Krasnoyarsk
V. E. Bezzabotnov
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: evgen_patolog@mail.ru
Russian Federation, Krasnoyarsk
