Enviar artigo por via de e-mail Antitumor Properties of Modified Detonation Nanodiamonds and Sorbed Doxorubicin on the Model of Ehrlich Ascites Carcinoma
- Autores: Medvedeva N.1, Zhukov E.1, Inzhevatkin E.1,2, Bezzabotnov V.1
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Afiliações:
- V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
- Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences
- Edição: Volume 160, Nº 3 (2016)
- Páginas: 372-375
- Seção: Nanobiotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/236710
- DOI: https://doi.org/10.1007/s10517-016-3174-z
- ID: 236710
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Resumo
We studied antitumor properties of modified detonation nanodiamonds loaded with doxorubicin on in vivo model of Ehrlich ascites carcinoma. The type of tumor development and morphological characteristics of the liver, kidneys, and spleen were evaluated in experimental animals. Modified nanodiamonds injected intraperitoneally produced no antitumor effect on Ehrlich carcinoma. However, doxorubicin did not lose antitumor activity after sorption on modified nanodiamonds.
Sobre autores
N. Medvedeva
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: evgen_patolog@mail.ru
Rússia, Krasnoyarsk
E. Zhukov
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: evgen_patolog@mail.ru
Rússia, Krasnoyarsk
E. Inzhevatkin
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation; Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences
Email: evgen_patolog@mail.ru
Rússia, Krasnoyarsk; Krasnoyarsk
V. Bezzabotnov
V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation
Email: evgen_patolog@mail.ru
Rússia, Krasnoyarsk
