The Preparation of Convencent Plasma and Recruiting of Donors during the COVID-19 Pandemic

Alexandr I. Kostin; Костин Александр Игоревич; Sergey S. Petrikov; Петриков Сергей Сергеевич; Nataliya V. Borovkova; Боровкова Наталья Валерьевна; Natal’ya V. Doronina; Доронина Наталья Викторовна; Mihail A. Godkov; Годков Михаил Андреевич; Irina B. Simarova; Симарова Ирина Борисовна; Olga A. Mayorova; Майорова Ольга Андреевна; Kira S. Momotyuk; Момотюк Кира Сергеевна; Violetta V. Danilec; Данилец Виолетта Вячеславовна; Irina A. Yarotskaya; Яроцкая Ирина Анатольевна; Alexandr L. Gincburg; Гинцбург Александр Леонидович; Alexey I. Hripun; Хрипун Алексей Иванович; Denis Y. Logunov; Логунов Денис Юрьевич; Inna V. Dolschikova; Должикова Инна Вадимовна; Alexey I. Mazus; Мазус Алексей Израилевич; Elena Y. Vasilyeva; Васильева Елена Юрьевна; Evgenij A. Vasin; Васин Евгений Анатольевич; Vladimir V. Ganchin; Ганчин Владимир Владимирович; Evgeniy L. Nikonov; Никонов Евгений Леонидович; Alexey V. Pinchuk; Пинчук Алексей Валерьевич; Andrey Y. Bulanov; Буланов Андрей Юльевич; Mar’yana A. Lisenko; Лысенко Марьяна Анатольевна

doi:10.15690/vramn1432

The Preparation of Convencent Plasma and Recruiting of Donors during the COVID-19 Pandemic

作者: Kostin A.I.¹, Petrikov S.S.¹, Borovkova N.V.¹, Doronina N.V.¹, Godkov M.A.¹, Simarova I.B.¹^,2, Mayorova O.A.³, Momotyuk K.S.³, Danilec V.V.⁴, Yarotskaya I.A.⁴, Gincburg A.L.⁵, Hripun A.I.⁶, Logunov D.Y.⁵, Dolschikova I.V.⁵, Mazus A.I.⁷, Vasilyeva E.Y.⁸, Vasin E.A.², Ganchin V.V.⁹, Nikonov E.L.⁶, Pinchuk A.V.¹^,10, Bulanov A.Y.², Lisenko M.A.²
隶属关系:
1. N.V. Sklifosovsky Research Institute of Emergency Medicine, Moscow Department of Healthcare
2. 52th City Clinical Hospital
3. Blood Center O.K. Gavrilova Moscow Department of Healthcare
4. City Clinical Hospital M.P. Konchalovskiy
5. National Research Center of Epidemiology and Microbiology N.F. Gamaleya of the Ministry of Health of the Russian Federation
6. Moscow Department of Healthcare
7. Moscow City AIDS Prevention and Control Center of the City Health Department
8. City Clinical Hospital I.V. Davydovsky
9. Autonomous non-commercial organizations “Center of Analytical Development of the Social Sector”
10. Research Institute for Healthcare Organization and Medical Management
期: 卷 75, 编号 5S (2020)
页面: 446-454
栏目: INFECTIOUS DISEASES: CURRENT ISSUES
URL: https://journals.rcsi.science/vramn/article/view/125735
DOI: https://doi.org/10.15690/vramn1432
ID: 125735

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Background. The pandemic of the new coronavirus infection has challenged the medical community for quickly finding and implementing effective methods of treatment. In the absence of a vaccine or specific therapy with proven effectiveness, the usage of convalescent plasma can be the one of perspective methods. An important aspect of this technology is the efficient and safe preparation of convalescent plasma. To date, in the world literature there are practically no publications about donor recruitment and the specifics of the preparation of convalescent plasma.

Purpose of the research. Presentation of the experience of organizing a workflow for recruiting donors and stockpiling of convalescent plasma with a high titer of virus-neutralizing antibodies to SARS-CoV-2.

Methods. The analysis of the work of the Blood Service of the Moscow Department of Health for stockpiling of COVID-19 convalescent plasma has been executed. In total it has been stockpiled 1240 doses. The normative documentation has been developed by a working group on the basis of the current federal legislation of Russian federation and been approved by the Moscow Department of Health. The titer of neutralizing antibodies (VNA) has been determined as the basic method for assessing the immunological viability of convalescent plasma. The main characteristics of donors, the characteristics of the disease course, the results of preliminary testing for the presence of specific antibodies by ELISA and CLIA methods has been compared with VNA titers in the stockpiled convalescent plasma.

Results. Due to a Moscow Health Department’s order No. 325 dated 01.04.2020 (a basic local regulatory document) it has been developed a regulation for the stockpiling, examination, storage, safety and transfering of fresh frozen pathogen-reduced plasma of COVID-19 convalescent donors to medical organizations of the Moscow Health Department. For arranging an interaction with donors it has been created a call-center. For effective preliminary selection, it has been formed a donor characteristics list, which has been combined with screening of specific antibodies by ELISA and CLIA methods.

Conclusions. Developed a system of recruiting donors and procurement process of convalescent plasma for treatment СOVID-19, which includes the necessary regulations, algorithms for the selection and recruitment of donors, the registry of donors and recipients, algorithms, efficiency and safety of convalescent plasma.

关键词

COVID-19, convalescent plasma, blood donation