The influence of pseudoexfoliative syndrome on corneal morphology based on in vivo confocal microscopy

封面

如何引用文章

全文:

详细

Background: Confocal microscopy is a modern examination method that enables real-time, noninvasive in vivo imaging of the cornea, limb, and conjunctiva.

Aim: To evaluate the main morphological changes observed using confocal microscopy in patients with pseudoexfoliation (PEX) syndrome.

Methods: Overall, 21 patients were examined: 12 with PEX syndrome were enrolled in the examination group and nine patients without PEX in the control group.

Results: In patients with PEX, a decreased cell density in the epithelium and stroma of the cornea as well as a significant increase of hyper-reflective intercellular microdeposits and dendritic cells was observed (p < 0.05).

作者简介

Vitaly Potemkin

I.P. Pavlov First St Petersburg State Medical University

编辑信件的主要联系方式.
Email: potem@inbox.ru

PhD, assistant professor. Department of Ophthalmology

俄罗斯联邦, Saint Petersburg

Tatyana Varganova

Saint Petersburg State Hospital No 2

Email: varganova.ts@yandex.ru

Ophthalmologist

俄罗斯联邦, Saint Petersburg

Evgeniy Akopov

I.P. Pavlov First St Petersburg State Medical University

Email: elacop@mail.ru

PhD, assistant professor. Department of Ophthalmology

俄罗斯联邦, Saint Petersburg

Elena Ageeva

I.P. Pavlov First St Petersburg State Medical University

Email: ageeva_elena@inbox.ru

resident. Department of Ophthalmology

俄罗斯联邦, Saint Petersburg

参考

  1. Потемкин В.В., Агеева Е.В. Состояние глазной поверхности при псевдоэксфолиативном синдроме // Учёные записки СПбГМУ им. акад. И.П. Павлова. – 2016. – Т. 23. – № 1. – С. 47–50. [Potemkin VV, Ageeva EV. Sostojanie glaznoj poverhnosti pri psevdojeksfoliativnom syndrome. Uchjonye zapiski SPbGMU im. akad. I.P. Pavlova. 2016;23(1):47-50 (In Russ.)]
  2. Kocabeyoğlu S, İrkec M, Orhan M, Mocan M. Evaluation of the Ocular Surface Parameters in Pseudoexfoliation Syndrome and Conjunctivochalasis. Hacettepe University School of Medicine, Department of Ophthalmology. 2012.
  3. Ritch R, Schlotzer-Schrehardt U. Exfoliation syndrome. Survey of Ophthalmology. 2001;45:265-313.
  4. Schumacher S, Schlötzer-Schrehardt U, Martus P, et al. Pseudoexfoliation syndrome and aneurysms of the abdominal aorta. Lancet. 2001;357:359-360.
  5. Schlötzer-Schrehardt U, Naumann GO. Ocular and systemic pseudoexfoliation syndrome. Am J Ophthalm. 2006:921-937.
  6. Summanen P, Tönjum AM. Exfoliation syndrome. Act Ophthalmol Suppl. 1998;184:107-111
  7. Schlötzer-Schrehardt U, Koca M, Naumann GO, Volkholz H. Pseudoexfoliation syndrome: ocular manifestation of a systemic disorder. Arch Ophthalmol. 1992;110:1752-1756.
  8. Zheng Х, Shiraishi A, Okuma Sh, et al. In Vivo Confocal Microscopic Evidence of Keratopathy in Patients with Pseudoexfoliation Syndrome, Investigative Ophthalmology & Visual Science March. 2011;52:1755-1761.
  9. Naumann GOH, Schlötzer-Schrehardt U. Keratopahty in pseudoexfoliation syndrome as a cause of corneal endothelial decompensation - a clinicopathologic. Ophthalmology. 2000;107:1111-1124.
  10. Kozobolis VP, Christodoulakis EV, Naoumidi II, et al. Study of conjunctival goblet cell morphology and tear film stability in pseudoexfoliation syndrome. Graefes Arch Clin Exp Ophthalmol. 2004;242:478-483study. Ophthalmology. 2000;107:1111-1124.
  11. Detorakis ET, Koukoula S, Chrisohoou F, et al. Central corneal mechanical sensitivity in pseudoexfoliation syndrome. Cornea. 2005;24:688-691.
  12. Ткаченко Н.В., Астахов С.Ю. Диагностические возможности конфокальной микроскопии при исследовании поверхностных структур глазного яблока // Офтальмологические ведомости. – 2009. – Т. 2. – № 1. [Tkachenko NV, Astahov SJu. Diagnosticheskie vozmozhnosti konfokal’noj mikroskopii pri issledovanii poverhnostnyh struktur glaznogo jabloka. Oftal’mologicheskie vedomosti. 2009;2(1). (In Russ.)]
  13. Oliveira - Soto L, Efron N. Morphology of corneal nerves using confocal microscopy. Cornea. 2001;20(4):374-384.
  14. Patel S, McLaren J, Hodge D, et al. Normal human keratocyte density and corneal thickness measurement by using confocal microscopy in vivo. Invest Ophthalmol Vis Sci. 2001;42(2)333-339.
  15. Zhang M, Chen J, Luo L, et al. Altered corneal nerves in aqueous tear deficiency viewed by in vivo confocal microscopy. Cornea. 2005;24:818-824.
  16. Zhang X, Chen Q, Chen W, et al. Tear dynamics and corneal confocal microscopy of subjects with mild self-reported office dry eye. Ophthalmology. 2011;118:902-907.
  17. Азнабаев Б.М. Лазерная сканирующая томография глаза: передний и задний сегмент. – М., 2008. [Aznabaev BM. Lazernaja skanirujushhaja tomografija glaza: perednij i zadnij segment. Moscow, 2008. (In Russ.)]
  18. Jalbert I, Stapleton F, Papas E, et al. In vivo confocal microscopy of the human cornea. Br J Ophthalmol. 2003;87(2):225-236.
  19. Mastropasqua L, Nubile M. Confocal Microscopy of the Cornea. SLACK Incorporated USA. 2002:122.
  20. Maurer JK, Jester JV. Use of the vivo confocal microscopy to understand the pathology of accidental ocular irritaition. Toxicol Pathol. 1999;27(1):44-47.
  21. Masters BR, Thaer A. Real-time scanning slit confocal microscopy of the in vivo human cornea. Applied Optics. 1994;33:695-701.
  22. Kinard KI, Smith AG, Singleton JR, et al. Chronic migraine is associated with reduced corneal nerve fiber density and symptoms of dry eye. Headache. 2015;55(4):543-549.
  23. Martone G, Casprini F, Traaversi C, et al. Pseudoexfoliation syndrome: in vivo confocal microscopy analysis. Clin Exp Ophthalmol. 2007;35:582-585.
  24. Sbeity Z, Palmiero PM, Tello C, et al. Non-contact in vivo confocal scanning laser microscopy in exfoliation syndrome, exfoliation syndrome suspect and normal eyes. Acta Ophthalmol. 2009 Oct 23.
  25. Tomaszewski BT, Zalewska R, Mariak Z. Evaluation of the Endothelial Cell Density and the Central Corneal Thickness in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. Journal of Ophthalmology. 2014; 20143. doi: 10.1155/2014/123683. [PubMed]
  26. Oltulu, Refik, Satirtav,net al. Characteristics of the cornea in patients with pseudoexfoliation syndrome. Arquivos Brasileiros de Oftalmologia. ;78(6) 348-351.
  27. Demirdögen BC, Ceylan OM, Isikoglu S,Oet al. Evaluation of oxidative stress and paraoxonase phenotypes in pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Clin Lab. 2014;60(1):79-86.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Potemkin V.V., Varganova T.S., Akopov E.L., Ageeva E.V., 2017

Creative Commons License
此作品已接受知识共享署名 4.0国际许可协议的许可
 


##common.cookie##