The influence of local IOP-lowering therapy on the anterior segment tissues and outcome of glaucoma filtering surgery
- Authors: Petrov S.Y.1, Lovpache D.N.2, Loskutov I.A.3, Safonova D.M.1
-
Affiliations:
- Scientific Research Institute of Eye Diseases
- Moscow Helmholtz Research Institute of Eye Diseases
- Scientific Clinical Center of Russian Railways
- Issue: Vol 10, No 4 (2017)
- Pages: 41-47
- Section: Articles
- URL: https://journals.rcsi.science/ov/article/view/7787
- DOI: https://doi.org/10.17816/OV10441-47
- ID: 7787
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Abstract
Nowadays, a wide choice of local IOP-lowering medications allows ensuring a successful intraocular pressure compensation and primary open angle glaucoma stabilization. However, taking into consideration a long term action of drugs on the ocular surface, even without clinical manifestations there is a direct inflammatory cells’ activation with mixed toxic and allergic changes, which is confirmed by histology, immune-histology, and impression cytology methods. Such chronic sub-clinical inflammation represent a potential risk of excessive fibroblast proliferation with subsequent rapid postoperative scarring of new outflow pathways and atypical filtration bleb formation. It is shown that there is a clear relationship between number of glaucoma drugs used, treatment duration, intensity of conjunctival infiltration with inflammatory cells and fibroblasts, and risk of episcleral fibrosis and subconjunctival scarring during post-op period.
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##article.viewOnOriginalSite##About the authors
Sergej Yu. Petrov
Scientific Research Institute of Eye Diseases
Author for correspondence.
Email: post@glaucomajournal.ru
PhD, leading research associate, Glaucoma Department
Russian Federation, MoscowDzhamilya N. Lovpache
Moscow Helmholtz Research Institute of Eye Diseases
Email: dlovpache@mail.ru
PhD, senior research associate, Glaucoma Department
Russian Federation, MoscowIgor' A. Loskutov
Scientific Clinical Center of Russian Railways
Email: loskoutigor@mail.ru
Professor, DMedSc, Head of the Clinical Center
Russian Federation, MoscowDaria M. Safonova
Scientific Research Institute of Eye Diseases
Email: dmsafonova@gmail.com
PhD, Junior Research Associate, Phacoemulsification and Intraocular Correction Department
Russian Federation, MoscowReferences
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