A comparative study of bowman layer transplantation results without and after ultraviolet crosslinking in advanced keratoconus
- Authors: Oganesyan O.G.1,2, Getadaryan V.R.1, Makarov P.V.1, Ashikova P.M.1, Ignatieva N.Y.3
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Affiliations:
- Helmholtz National Medical Research Center of Eye Diseases
- A.I. Evdokimov Moscow State University of Medicine and Dentistry
- Lomonosov Moscow State University
- Issue: Vol 13, No 1 (2020)
- Pages: 17-27
- Section: Original researches
- URL: https://journals.rcsi.science/ov/article/view/19145
- DOI: https://doi.org/10.17816/OV19145
- ID: 19145
Cite item
Abstract
Aim. A comparative study of Bowman layer transplantation (BLT) after its ultraviolet (UV) crosslinking and BLT without preliminary UV crosslinking in patients with advanced keratoconus (KC) stages III to IV.
Materials and methods. There were 30 patients aged 14 to 37 years with KC III–IV stages. The first group included 15 patients who underwent BLT without prior UV crosslinking. The second group included 15 patients who underwent BLT after UV crosslinking. The criteria for inclusion of patients in the study were: progressive KC, with corneal thinnest point (CTP) without epithelium of 400 μm or less, a maximum keratometric index (Kmax) of 58 D and more, with patient satisfied by his visual acuity in a scleral contact lens (SCL) and refusing keratoplasty.
Results. In comparison with preoperative data in both groups, Kmax decreased by an average 0.6 ± 0.5 D, and CTP increased in the first group by an average of 41.5 ± 16.3 µm, and in the second group by an average of 31,9 ± 9.2 μm. Best corrected visual acuity (BCVA) did not change.
Conclusion. During the follow-up of 26.6 ± 6.2 (from 6 to 36) months, CTP and Kmax indices remained stable in operated patients, which indicates the arrest of KC progression after BLT with crosslinking and without it. The preservation of endothelial cell density and BCVA values indicates the safety of both methods.
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##article.viewOnOriginalSite##About the authors
Oganes G. Oganesyan
Helmholtz National Medical Research Center of Eye Diseases; A.I. Evdokimov Moscow State University of Medicine and Dentistry
Email: oftalmolog@mail.ru
PhD; Professor, Eye Diseases Department
Russian Federation, MoscowVostan R. Getadaryan
Helmholtz National Medical Research Center of Eye Diseases
Author for correspondence.
Email: vostan11@gmail.com
MD
Russian Federation, MoscowPavel V. Makarov
Helmholtz National Medical Research Center of Eye Diseases
Email: makarovpavel61@mail.ru
PhD
Russian Federation, MoscowPatimat M. Ashikova
Helmholtz National Medical Research Center of Eye Diseases
Email: patiyago@mail.ru
MD
Russian Federation, MoscowNataliya Yu. Ignatieva
Lomonosov Moscow State University
Email: n.yu.ignatieva@gmail.com
Dr. Chem. Sci.
Russian Federation, MoscowReferences
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