Comparative assessment of the efficacy of primary and secondary corneal endothelial dystrophy treatment by isolated descemetorhexis and accelerated collagen crosslinking method

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Abstract

The article examines the efficacy of the author’s method of endothelial corneal dystrophy treatment, inclu ding descemetorhexis and accelerated collagen crosslinking. In primary endothelial dystrophy, corneal state improvement and restoration of its transparency were observed in 66.6% of cases (due to migration of endothelial cells from the periphery to the сentral zone). In secondary endothelial dystrophy, the treatment method described in the present article is ineffective, and the reasons for failures are not quite clear and require further investigation.

About the authors

Sergey Yu. Astakhov

Academician I.P. Pavlov First St. Petersburg State Medical University

Author for correspondence.
Email: astakhov73@mail.ru

MD, PhD, DMedSc, Professor, Head of the Department. Ophthalmology Department

Russian Federation, Saint Petersburg

Inna A. Riks

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: riks0503@yandex.ru

MD, PhD, Assistant. Ophthalmology Department

Russian Federation, Saint Petersburg

Sanasar S. Papanyan

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: dr.papanyan@yandex.ru

MD, Aspirant. Ophthalmology Department

Russian Federation, Saint Petersburg

Sergey A. Novikov

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: serg2705@yandex.ru

MD, PhD, DMedSc, Professor. Ophthalmology Department

Russian Federation, Saint Petersburg

Georgiy Z. Dzhaliashvili

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: zurabych@yandex.ru

Ophthalmologist

Russian Federation, Saint Petersburg

Irina B. Bondareva

Academician I.P. Pavlov First St. Petersburg State Medical University

Email: ibbondareva@rambler.ru

MD, Ophthalmology Department

Russian Federation, Saint Petersburg, Russia

References

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Supplementary files

Supplementary Files
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2. Fig. 1. Patient G., 69 years, with Fuchs endothelial corneal dystrophy before treatment

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3. Fig. 2. Patient R., 63 years, with Fuchs endothelial corneal dystrophy before treatment

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4. Fig. 3. Patient D., 64 years, with the secondary ED before treatment

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5. Fig. 4. Patient K., 68 years, with the secondary ED before treatment

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6. Fig. 5. Сornea with Fuchs endothelial corneal dystrophy before treatment (a); 2 days after the isolated DR and ACXL and phacoemulsification with intraocular lens implantation (b)

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7. Fig. 6. Cornea after the isolated DR and ACXL (arrows indicate the folds of the deep layers of the stroma)

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8. Fig. 7. The restoration of corneal transparency 1,5 months after the isolated DR and ACXL (arrows indicate the border of the descemetorhexis)

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9. Fig. 8. Confocal microscopy of endothelial cells (1503 cells/mm2) 3 months after the isolated DR and ACXL (а); confocal micro scopy of endothelial cells (1693 cells/mm2) 3.5 months after the isolated DR and ACXL (b)

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10. Fig. 9. Patient S., 77 years, with the secondary ED 8 months after the isolated DR and ACXL with negative dynamics

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11. Fig. 10. Patient R., 68 years, with the secondary ED 8 months after the isolated DR and ACXL with negative dynamics

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Copyright (c) 2018 Astakhov S.Y., Riks I.A., Papanyan S.S., Novikov S.A., Dzhaliashvili G.Z., Bondareva I.B.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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