Evaluation of retinal thickness and of pseudophakic cystoid macular edema incidence in patients with primary open-angle glaucoma treated with prostaglandin analogues

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Background. Cataract is often associated with primary glaucoma. Prostaglandin analogues use is considered to be a risk factor for pseudophakic cystoid macular edema.

Purpose. To evaluate the effect of prostaglandin analogues and non-steroidal anti-inflammatory drops on the central retinal thickness and the incidence of pseudophakic cystoid macular edema after phacoemulsification with intraocular lens implantation in patients with primary open-angle glaucoma.

Materials and methods. 91 patients were enrolled in the study. 22 patients (22 eyes) were included in the first main group and 22 patients (22 eyes) were included in the second main groups. All patients in main groups had glaucoma and used prostaglandin analogues. 47 patients (57 eyes) without glaucoma were included in the control group. All patients were treated with topical antibiotics and steroids after phacoemulsification. Patients in the main second and in the control groups also received non-steroidal anti-inflammatory drops. The retinal thickness was measured by optical coherence tomography 2 weeks, 2 months and 6 months after the operation.

Results. After the operation, the foveal thickness in patients of the first and the second groups was increased, but it had returned to the preoperative level after 6 months in the first group and after 2 months in the second group. The retinal thickness in the fovea in the control group decreased after the surgery and it has been increasing gradually but did not achieve the preoperative value.

Conclusion. Prostaglandin analogues use after phacoemulsification with intraocular lens implantation does not affect the incidence of pseudophakic cystoid macular edema. Prescribing non-steroidal anti-inflammatory drops after the surgery helps to achieve faster normalization of the central retinal thickness.

About the authors

Xiaoyuan Wang

Pavlov First St. Petersburg State Medical University

Email: wangxiaoyuan20121017@gmail.com
ORCID iD: 0000-0002-1135-6796

PhD student

Russian Federation, 6–8 L’va Tolstogo str., Saint Petersburg, 197022

Sergey Yu. Astakhov

Pavlov First St. Petersburg State Medical University

Email: astakhov73@mail.ru
ORCID iD: 0000-0003-0777-4861
SPIN-code: 7732-1150
Scopus Author ID: 56660518500

Dr. Sci. (Med.), professor

Russian Federation, 6–8 L’va Tolstogo str., Saint Petersburg, 197022

Vitaly V. Potemkin

City Multidiscipline Hospital No. 2

Email: potem@inbox.ru
ORCID iD: 0000-0001-7807-9036
SPIN-code: 3132-9163

Cand. Sci. (Med.)

Russian Federation, 5 Uchebniy pereulok, Saint Petersburg, 194354

Albina R. Potemkina

City Multidiscipline Hospital No. 2

Email: prinzabiyka@mail.ru

ophthalmologist

Russian Federation, 5 Uchebniy pereulok, Saint Petersburg, 194354

Liliya K. Anikina

Pavlov First St. Petersburg State Medical University

Author for correspondence.
Email: lily-sai@yandex.ru
ORCID iD: 0000-0001-8794-0457

medical resident

Russian Federation, 6–8 L’va Tolstogo str., Saint Petersburg, 197022

References

  1. Scholl S, Kirchhof J, Augustin AJ. Pathophysiology of macular edema. Ophthalmologica. 2010;224 Suppl 1:8–15. doi: 10.1159/000315155
  2. Irvine SR. A newly defined vitreous syndrome following cataract surgery. Am J Ophthalmol. 1953;36(5):599–619. doi: 10.1016/0002-9394(53)90302-x
  3. Gass JD, Norton EW. Cystoid macular edema and papilledema following cataract extraction. A fluorescein fundoscopic and angiographic study. Arch Ophthalmol. 1966;76(5):646–661. doi: 10.1001/archopht.1966.03850010648005
  4. Gass JD, Norton EW. Fluorescein studies of patients with macular edema and papilledema following cataract extraction. Trans Am Ophthalmol Soc. 1966;64:232–249.
  5. Han JV, Patel DV, Squirrell D, McGhee CN. Cystoid macular oedema following cataract surgery: A review. Clin Exp Ophthalmol. 2019;47(3):346–356. doi: 10.1111/ceo.1351
  6. Flach AJ. The incidence, pathogenesis and treatment of cystoid macular edema following cataract surgery. Trans Am Ophthalmol Soc. 1998;96:557–634.
  7. Ioshin IE. Postoperative, or pseudophakic, macular edema. Russian Ophthalmological Journal. 2020;13(4):64–69. (In Russ.) doi: 10.21516/2072-0076-2020-13-4-64-69
  8. Hwang HS, Ahn YJ, Lee HJ, et al. Comparison of macular thickness and inflammatory cytokine levels after microincision versus small incision coaxial cataract surgery. Acta Ophthalmol. 2016;94(3): e189–194. doi: 10.1111/aos.12716
  9. Gulkilik G, Kocabora S, Taskapili M, Engin G. Cystoid macular edema after phacoemulsification: risk factors and effect on visual acuity. Can J Ophthalmol. 2006;41(6):699–703. doi: 10.3129/i06-062
  10. Yonekawa Y, Kim IK. Pseudophakic cystoid macular edema. Curr Opin Ophthalmol. 2012;23(1):26–32. doi: 10.1097/ICU.0b013e32834cd5f8
  11. Lobo C. Pseudophakic cystoid macular edema. Ophthalmologica. 2012;227(2):61–67. doi: 10.1159/000331277
  12. Kokorev VL. The Analysis of Risk Factors of Development of Macular Edema after Phacoemulsification. Ophthalmology in Russia. 2019;16(2):185–191. (In Russ.) doi: 10.18008/1816-5095-2019-2-185-191
  13. Erichev VP, Kozlova IV, Kosova DV, et al. Dynamics of changes in morphometric parameters of the macular zone in glaucoma patients after phacoemulsification. The Russian Annals of Ophthalmology. 2019;135(5–2):129–134. (In Russ.) doi: 10.17116/oftalma2019135052129
  14. Gharbiya M, Cruciani F, Cuozzo G, et al. Macular thickness changes evaluated with spectral domain optical coherence tomography after uncomplicated phacoemulsification. Eye (Lond). 2013;27(5):605–611. doi: 10.1038/eye.2013.28
  15. Iliff WJ. Aphakic cystoid macular edema and the operating microscope: is there a connection? Trans Am Ophthalmol Soc. 1985;83:476–500.
  16. Astakhov SYu, Gobedzhishvili MV. Postoperative macular edema, syndrome Irvine Gass. Clinical Ophthalmology. 2010;11(1):5–8. (In Russ.)
  17. Kessel L, Tendal B, Jørgensen KJ, et al. Post-cataract prevention of inflammation and macular edema by steroid and nonsteroidal anti-inflammatory eye drops: a systematic review. Ophthalmology. 2014;121(10):1915–1924. doi: 10.1016/j.ophtha.2014.04.035
  18. Astakhov SY, Astakhov YS, Gobedzhishvili MV. The influence of prostaglandin analogs on the retinal thickness after phacoemulsification with intraocular lens implantation in primary open-angle glaucoma patients. Ophthalmology Journal. 2014;7(3):73–76. (In Russ.) doi: 10.17816/OV2014373-76
  19. Miyake K, Ibaraki N. Prostaglandins and cystoid macular edema. Surv Ophthalmol. 2002;47 Suppl 1: S203–S218. doi: 10.1016/s0039-6257(02)00294-1
  20. Warwar RE, Bullock JD, Ballal D. Cystoid macular edema and anterior uveitis associated with latanoprost use. Experience and incidence in a retrospective review of 94 patients. Ophthalmology. 1998;105(2):263–268. doi: 10.1016/s0161-6420(98)92977-3
  21. Lima MC, Paranhos A Jr, Salim S, et al. Visually significant cystoid macular edema in pseudophakic and aphakic patients with glaucoma receiving latanoprost. J Glaucoma. 2000;9(4):317–321. doi: 10.1097/00061198-200008000-00006
  22. Camras CB, Alm A, Watson P, Stjernschantz J. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Latanoprost Study Groups. Ophthalmology. 1996;103(11):1916–1924. doi: 10.1016/s0161-6420(96)30407-7
  23. Yousufzai SY, Ye Z, Abdel-Latif AA. Prostaglandin F2 alpha and its analogs induce release of endogenous prostaglandins in iris and ciliary muscles isolated from cat and other mammalian species. Exp Eye Res. 1996;63(3):305–310. doi: 10.1006/exer.1996.0119
  24. Javadova GCh, Ioshin IE, Musayev PI, Guliyeva ST. The role of prostaglandin analogs in the development of macular edema on their perioperative application in patients suff ering from cataract with concurrent primary open-angle glaucoma. Vestnik of Vitebsk State Medical University. 2019. Vol. 18, No. 6. P. 8–15. (In Russ.) doi: 10.22263/2312-4156.2019.6.8
  25. Miyake K, Ota I, Maekubo K, et al. Latanoprost accelerates disruption of the blood-aqueous barrier and the incidence of angiographic cystoid macular edema in early postoperative pseudophakias. Arch Ophthalmol. 1999;117(1):34–40. doi: 10.1001/archopht.117.1.34
  26. Arcieri ES, Santana A, Rocha FN, et al. Blood-aqueous barrier changes after the use of prostaglandin analogues in patients with pseudophakia and aphakia: a 6-month randomized trial. Arch Ophthalmol. 2005;123(2):186–192. doi: 10.1001/archopht.123.2.186
  27. Yüksel N, Doğu B, Karabaş VL, Cağlar Y. Foveal thickness after phacoemulsification in patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, or primary open-angle glaucoma. J Cataract Refract Surg. 2008;34(11):1953–1957. doi: 10.1016/j.jcrs.2008.07.016
  28. Puliafito CA, Hee MR, Lin CP, et al. Imaging of macular diseases with optical coherence tomography. Ophthalmology. 1995;102(2):217–229. doi: 10.1016/s0161-6420(95)31032-9
  29. Jaffe GJ, Caprioli J. Optical coherence tomography to detect and manage retinal disease and glaucoma. Am J Ophthalmol. 2004;137(1):156–169. doi: 10.1016/s0002-9394(03)00792-x
  30. Chu CJ, Johnston RL, Buscombe C, et al. Risk Factors and Incidence of Macular Edema after Cataract Surgery: A Database Study of 81984 Eyes. Ophthalmology. 2016;123(2):316–323. doi: 10.1016/j.ophtha.2015.10.001
  31. Alekseev IB, Samoylenko AI, Adleyba OA, et el. The impact of prostaglandin analogs on the results of cataract phacoemulsification in patients with primary open-angle glaucoma. Russian Ophthalmological Journal. 2012;5(2):4–7. (In Russ.)
  32. von Jagow B, Ohrloff C, Kohnen T. Macular thickness after uneventful cataract surgery determined by optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2007;245(12):1765–1771. doi: 10.1007/s00417-007-0605-6
  33. Perente I, Utine CA, Ozturker C, et al. Evaluation of macular changes after uncomplicated phacoemulsification surgery by optical coherence tomography. Curr Eye Res. 2007;32(3):241–247. doi: 10.1080/02713680601160610
  34. Ching HY, Wong AC, Wong CC, et al. Cystoid macular oedema and changes in retinal thickness after phacoemulsification with optical coherence tomography. Eye (Lond). 2006;20(3):297–303. doi: 10.1038/sj.eye.6701864
  35. Kurt A, Kılıç R. The Effects of Uncomplicated Cataract Surgery on Retinal Layer Thickness. Journal of Ophthalmology.2018;2018:1–6. doi: 10.1155/2018/7218639
  36. Cagini C, Fiore T, Iaccheri B, et al. Macular thickness measured by optical coherence tomography in a healthy population before and after uncomplicated cataract phacoemulsification surgery. Curr Eye Res. 2009;34(12):1036–1041. doi: 10.3109/02713680903288937
  37. Falcão MS, Gonçalves NM, Freitas-Costa P, et al. Choroidal and macular thickness changes induced by cataract surgery. Clin Ophthalmol. 2014;8:55–60. doi: 10.2147/OPTH.S53989
  38. Degenring RF, Vey S, Kamppeter B, et al. Effect of uncomplicated phacoemulsification on the central retina in diabetic and non-diabetic subjects. Graefes Arch Clin Exp Ophthalmol. 2007;245(1):18–23. doi: 10.1007/s00417-006-0377-4
  39. Wielders LHP, Schouten JSAG, Winkens B, et al. European multicenter trial of the prevention of cystoid macular edema after cataract surgery in nondiabetics: ESCRS PREMED study report 1. 2018;44(9):1166. J Cataract Refract Surg. 2018;44(4):429–439. doi: 10.1016/j.jcrs.2018.01.029

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Dynamics of foveal thickness at different follow-up periods in groups

Download (199KB)
Indexing metadata
3. Fig. 2. Dynamics of the difference from the initial level of foveal thickness at different follow-up periods of observation in groups

Download (157KB)
Indexing metadata

Copyright (c) 2021 Wang X., Astakhov S.Y., Potemkin V.V., Potemkina A.R., Anikina L.K.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies