New options for the diagnosis of normal tension glaucoma in the light of Professor V.V. Volkov’s concept of its pathogenesis

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Abstract

PURPOSE: To measure lamina cribrosa thickness (LCT) and lamina cribrosa depth (LCD), optic nerve subarachnoid space width (ONSASW) in patients with normal tension glaucoma and in healthy individuals and to compare these data with the results of our own pilot study.

MATERIALS AND METHODS: The 1st group included 13 patients (22 eyes) with normal tension glaucoma aged 39 to 88 years (59.8 ± 10.9 years). The 2nd (control) group included 10 healthy people (20 eyes) aged 40 to 59 years (47.9 ± 5.5 years). All subjects underwent structural and functional assessment of the optic nerve head using optical coherent tomograph (OCT) RTVue-100 (Optovue, USA), Humphrey perimeter (HFA II 745i, Germany-USA), and our own modification of Frequency Doubling Technology perimetry. LCT and LCD were measured by OCT RS-3000 Advance (Nidek, Japan). To measure ONSASW we used a cross-sectional image of the optic nerve taken with Magnetic Resonance Imaging (GE Optima MR450w MRI, USA).

RESULTS: Differences in the 1st and 2nd groups between the mean values of LCT (234.14 ± 27.73 and 336.25 ± 21.0 μm, respectively; p = 0.0000), LCD (461.8 ± 101.7 and 361.65 ± 58.2 μm, respectively; p = 0.0004) and ONSASW (1.371 ± 0.035 and 1.52 ± 0.133 mm, respectively; p = 0.011) were statistically significant.

CONCLUSION: Patients with normal tension glaucoma had significantly higher LCD value with significantly lower LCT and ONSASW values compared to healthy individuals, which is comparable with the results of our pilot study, and confirms the importance of these morphometric criteria in normal tension glaucoma diagnosis verification.

About the authors

Irina L. Simakova

S.M. Kirov Military Medical Academy

Email: irina.l.simakova@gmail.com
ORCID iD: 0000-0001-8389-0421
SPIN-code: 3422-5512
Scopus Author ID: 7003824052
ResearcherId: M-3460-2016

MD, Dr. Sci. (Med.)

Russian Federation, 21 Botkinskaya st., Saint Petersburg, 194044

Alfina R. Suleimanova

S.M. Kirov Military Medical Academy

Email: alfinkamuse1@gmail.com
ORCID iD: 0000-0003-1893-8075

ophthalmologist

Russian Federation, 21 Botkinskaya st., Saint Petersburg, 194044

Natalya P. Baimuratova

S.M. Kirov Military Medical Academy

Author for correspondence.
Email: skynait@yandex.ru
ORCID iD: 0000-0001-5383-6440

roentgenologist

Russian Federation, 21 Botkinskaya st., Saint Petersburg, 194044

References

  1. Volkov VV, Simakova IL, Kulikov AN, et al. New morphometric criteria in the study of pathogenesis of normal-tension glaucoma. Vestnik Oftal’mologii. 2020;136(2):49–55. (In Russ.) doi: 10.17116/oftalma202013602149
  2. Hong C, Hong SW, Park CK, et al. Profiles and clinical characteristics of newly diagnosed glaucoma in urban Korea: a multicenter study. Korean J Ophthalmol. 2020;34(5):353–360. doi: 10.3341/kjo.2020.0033
  3. Killer HE, Pircher A. Normal tension glaucoma: review of current understanding and mechanisms of the pathogenesis. Eye. 2018;32(5):924–930. doi: 10.1038/s41433-018-0042-2
  4. Van Beuningen E, Fischer W. Methodical notes on tonographic and gonioscopy. Klin. Monatsbl Augenh. 1956;129(5):202–210. (In German)
  5. Duke-Elder SD. System of ophthalmology vol.11: diseases of the lens and vitreous; glaucoma and hypotony. London: Henry Kimpton Publisher; 1969.
  6. Volkov VV, Korovenkov RI. Ob urovne davleniya zhidkosti v mezhobolochechnykh prostranstvakh zritel’nogo nerva krolika. Fiziologicheskii zhurnal SSSR im. I.M. Sechenova. 1974;(61)93–196. (In Russ.)
  7. Morgan WH. The influence of cerebrospinal fluid pressure on the lamina cribrosa tissue pressure gradient. Investig Ophthalmol Vis Sci. 1995;36(6):1163–1172.
  8. Berdahl JP, Fautsch MP, Stinnett SS. Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case–control study. Investig Ophthalmol Vis Sci. 2008;49(12):5412–5418. doi: 10.1167/iovs.08-2228
  9. Ren R, Jonas JB, Tian G, et al. Cerebrospinal Fluid Pressure in Glaucoma. Ophthalmology. 2010;117(2):259–266. doi: 10.1016/j.ophtha.2009.06.058
  10. Volkov VV. Glaukoma pri psevdonormal’nom davlenii. Мoscow; 2001. (In Russ.)
  11. Volkov VV, Romova TYa. Obshchaya arterial’naya gipotenziya i glaukomatoznyi protsess v glazu. Vserossiiskoe obshchestvo oftal’mologov: materialy konferentsii. Ordzhonikidze. 1970:37–39. (In Russ.)
  12. Volkov VV, Sukhinina LB, Ustinova EI. Glaukoma, preglaukoma, oftal’mogipertenziya. Leningrad; 1985. (In Russ.)
  13. Volkov VV. Glaukoma otkrytougol’naya. Moscow; 2008. (In Russ.)
  14. Zhuravlev AI. Disk zritel’nogo nerva i zritel’nye funktsii v otsenke glaukomatoznogo protsessa. [dissertation]. Leningrad; 1986. (In Russ.)
  15. Simakova IL. Videogramma i disk zritel’nogo nerva pri raznykh stadiyakh otkrytougol’noi glaukomy i v otsenke effektivnosti ee operativnogo (khirurgicheskogo i lazernogo) lecheniya. [dissertation]. Saint Petersburg; 1997. (In Russ.)
  16. Volkov VV. Sushchestvennyi element glaukomatoznogo protsessa, ne uchityvaemyi v klinicheskoi praktike. Oftal’molo-gicheskii Zhurnal. 1976. № 7. С. 500–504. (In Russ.)
  17. Jonas JB. Role of cerebrospinal fluid pressure in the pathogenesis of glaucoma. Acta Ophthalmologica. 2011;89(6):505–514. doi: 10.1111/j.1755–3768.2010.01915.x
  18. Ren R, Wang N, Zhang X, et al. Trans-lamina cribrosa pressure difference correlated with neuroretinal rim area in glaucoma. Graefes Arch Clin Exp Ophthalmol. 2011;249(7):1057–1063. doi: 10.1007/s00417-011-1657-1
  19. Jóhannesson G, Eklund A, Lindén C. Intracranial and Intraocular Pressure at the Lamina Cribrosa: Gradient Effects. Curr Neurol Neurosci Rep. 2018;18(5):25–35. doi: 10.1007/s11910-018-0831-9
  20. Wang N, Xie X, Yang D, et al. Orbital Cerebrospinal Fluid Space in Glaucoma: The Beijing Intracranial and Intraocular Pressure (iCOP) Study. Ophthalmology. 2012;119(10):2065–2073. doi: 10.1016/j.ophtha.2012.03.054
  21. Park H-YL, Jeon SH, Park CK. Enhanced depth imaging detects lamina cribrosa thickness differences in normal tension glaucoma and primary Open-angle glaucoma. Ophthalmology. 2012;119(1): 10–20. doi: 10.1016/j.ophtha.2011.07.033
  22. Simakova IL, Volkov VV, Boiko EV. The results of developed method of frequency-doubling technology (FDT) perimetry in comparison with the results of the original FDT-perimetry. Glaucoma. 2010;(1):5–11. (In Russ.)
  23. Kim M, Bojikian KD, Slabaugh MA, et al. Lamina depth and thickness correlate with glaucoma severity. Indian J Ophthalmol. 2016;64(5):358–363. doi: 10.4103/0301-4738.185594
  24. Li L, Bian A, Cheng G, et al. Posterior displacement of the lamina cribrosa in normal-tension and high-tension glaucoma. Acta Ophthalmologica. 2016;94(6):492–500. doi: 10.1111/aos.13012
  25. Lee SH, Kim TW, Lee EJ, et al. Diagnostic Power of Lamina Cribrosa Depth and Curvature in Glaucoma. Investig Ophthalmol Vis Sci. 2017;58(2):755–762. doi: 10.1167/iovs.16-20802
  26. Cakmak S, Altan C, Topcu H, et al. Comparison of the Lami¬na Cribrosa Measurements Obtained by Spectral-Domain and Swept-Source Optical Coherence Tomography. Curr Eye Res. 2019;44(9):968–974. doi: 10.1080/02713683.2019.1604971
  27. Vianna JR, Lanoe VR, Quach J, et al. Serial changes in lamina cribrosa depth and neuroretinal parameters in glaucoma. Ophthalmology. 2017;124(9):1392–1402. doi: 10.1016/j.ophtha.2017.03.048
  28. Morozov VI, Yakovlev AA. Zabolevaniya zritel’nogo puti: klinika, diagnostika, lechenie. Moscow; 2010. (In Russ.)
  29. Lee JH, Lee HK, Kim JK, et al. CSF Flow Quantification of the Cerebral Aqueduct in Normal Volunteers Using Phase Contrast Cine MR Imaging. Korean J Radiol. 2004;5(2):81–86. doi: 10.3348/kjr.2004.5.2.81

Supplementary files

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2. Fig. 1. Lamina cribrosa depth measurement (a–b) by EDI (Enhanced Depth Imaging) mode of Nidek RS-3000 Advance

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3. Fig. 2. Lamina cribrosa thickness measurement (c–d) by EDI (Enhanced Depth Imaging) mode of Nidek RS-3000 Advance

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4. Fig. 3. Cross-sectional image of the optic nerve (right) taken 3 mm behind the eye using MRI. A–B – is the diameter of the optic nerve with its sheaths; C–D – is the diameter of the optic nerve without its sheaths

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5. Fig. 4. Comparison of cross-sectional slices of the optic nerve obtained with MRI Siemens Magnetom Symphony and MRI GE Optima MR450w

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6. Fig. 5. Average LCT values by the spectral OCT data in the enhanced depth imaging (EDI) mode in research work (a) and pilot study (b) in two groups (with 95% confidence intervals)

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7. Fig. 6. Average LCD values by the 3D OCT data in the enhanced depth imaging (EDI) mode in research work (а) and pilot study (b) in two groups (with 95% confidence intervals)

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8. Fig. 7. Average ONSASW values by the MRI data in research work (a) and pilot study (b) in two groups (with 95% confidence intervals)

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Copyright (c) 2021 Simakova I.L., Suleimanova A.R., Baimuratova N.P.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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