Email this article 
Post a Comment Myelinated retinal nerve fibers associated with retinal vascular abnormalities and retino-vitreal neovascularization complicated by recurrent vitreous hemorrhage (clinical case)
- Authors: Panfilova A.N.1, Doktorova T.A.2,3, Suetov A.A.2,4
-
Affiliations:
- Ophthalmological center “Vision”
- S. Fyodorov Eye Microsurgery Federal State Institution, Saint Petersburg Branch
- North-Western State Medical University named after I.I. Mechnikov
- State Scientific Research Test Institute of Military Medicine
- Issue: Vol 16, No 2 (2023)
- Pages: 91-97
- Section: Case reports
- URL: https://journals.rcsi.science/ov/article/view/253840
- DOI: https://doi.org/10.17816/OV119918
- ID: 253840
Cite item
Open Access
Access granted
Subscription Access
Abstract
Myelinated retinal nerve fibres are a rare, benign and asymptomatic lesion that is detected incidentally at fundus examination. In some cases, they may be associated with various abnormalities of the eye or have a complicated course. The article presents a clinical case of myelinated retinal nerve fibers associated with retinal vascular abnormalities and retino-vitreal neovascularization complicated by recurrent vitreous hemorrhage.
Full Text
##article.viewOnOriginalSite##About the authors
Anastasiya N. Panfilova
Ophthalmological center “Vision”
Email: panfilova@zrenie.spb.ru
ORCID iD: 0000-0002-8191-6090
ophthalmologist
Russian Federation, Saint PetersburgTaisiia A. Doktorova
S. Fyodorov Eye Microsurgery Federal State Institution, Saint Petersburg Branch; North-Western State Medical University named after I.I. Mechnikov
Author for correspondence.
Email: taisiiadok@mail.ru
ORCID iD: 0000-0003-2162-4018
SPIN-code: 8921-9738
postgraduate student, ophthalmologis
Russian Federation, Saint Petersburg; Saint PetersburgAleksei A. Suetov
S. Fyodorov Eye Microsurgery Federal State Institution, Saint Petersburg Branch; State Scientific Research Test Institute of Military Medicine
Email: ophtalm@mail.ru
ORCID iD: 0000-0002-8670-2964
SPIN-code: 4286-6100
МD, Cand. Sci. (Med.), ophthalmologist, senior research associate
Russian Federation, Saint Petersburg; Saint PetersburgReferences
- Shelton JB, Digre KB, Gilman J, et al. Characteristics of myelinated retinal nerve fiber layer in ophthalmic imaging: Findings on autofluorescence, fluorescein angiographic, infrared, optical coherence tomographic, and red-free images. Arch Ophthalmol. 2013;131(1):107–109. doi: 10.1001/jamaophthalmol.2013.560
- Straatsma BR, Foos RY, Heckenlively JR, Taylor GN. Myelinated retinal nerve fibers. Am J Ophthalmol. 1981;91(1):25–38. doi: 10.1016/0002-9394(81)90345-7
- Jean-Louis G, Katz BJ, Digre KB, et al. Acquired and progressive retinal nerve fiber layer myelination in an adolescent. Am J Ophthalmol. 2000;130(3):361–362. doi: 10.1016/S0002-9394(00)00550-X
- Ali BH, Logani S, Kozlov KL, et al. Progression of retinal nerve fiber myelination in childhood. Am J Ophthalmol. 1994;118(4):515–517. doi: 10.1016/S0002-9394(14)75805-2
- Fasiuddin KJ. Ocular findings associated with myelinated retinal nerve fibers. Cureus. 2021;13(4): e14552. doi: 10.7759/cureus.14552
- Berry-Brincat A, Shafquat S. Myelinated nerve fibres: a rare cause of recurrent vitreous haemorrhage. Eye. 2008;22:165–167. doi: 10.1038/sj.eye.6703002
- Hildebrand C, Remahl S, Persson H, Bjartmar C. Myelinated nerve fibres in the CNS. Prog Neurobiol. 1993;40(3):319–384. doi: 10.1016/0301-0082(93)90015-K
- Hunter SF, Leavitt JA, Rodriguez M. Direct observation of myelination in vivo in the mature human central nervous system. A model for the behaviour of oligodendrocyte progenitors and their progeny. Brain. 1997;120(11):2071–2082. doi: 10.1093/BRAIN/120.11.2071
- Fitzgibbon T, Nestorovski Z. Morphological consequences of myelination in the human retina. Exp Eye Res. 1997;65(6):809–819. doi: 10.1006/exer.1997.0388
- Tarabishy AB, Alexandrou TJ, Traboulsi EI. Syndrome of myelinated retinal nerve fibers, myopia, and amblyopia: a review. Surv Ophthalmol. 2007;52(6):588–596. doi: 10.1016/j.survophthal.2007.08.016
- Silvestri G, Sehmi K, Hamilton P. Retinal vascular abnormalities. A rare complication of myelinated nerve fibers? Retina. 1996;16(3):214–218. doi: 10.1097/00006982-199616030-00005
- Leys AM, Leys MJ, Hooymans JMM, et al. Myelinated nerve fibers and retinal vascular abnormalities. Retina. 1996;16(2):89–96. DOI: 1097/00006982-199616020-00001
- Minning CA, Davidorf FH. Neovascularization associated with myelinated nerve fibers: a case report. Ann Ophthalmol. 1983;15(12):1142–1144.
Supplementary files
Supplementary Files
Action
1.
JATS XML
2.
Fig. 1. Color fundus photography of a patient with myelinated nerve fibers complicated by vascular abnormalities (explanations in the text): a — general view, resolving vitreous hemorrhage (black arrows), laser burns after panretinal photocoagulation (blue arrows); b — myelinated retinal nerve fibers area with retino-vitreal neovascularization (arrow); c — structural OCT scan through the corresponding area; d, e — horizontal and vertical structural OCT scans through the center of the macula, in the fovea lamellar hole, epiretinal fibrosis, myelinated retinal nerve fibers extending into the fovea
Download (320KB)
3.
Fig. 2. Retinal fluorescein angiography data of a female patient with myelinated retinal fibers complicated by vascular abnormalities (explanations in the text): a — fundus image; b–d — hyperfluorescence of a fine, microvascular network with telangiectasias and neovascularization with signs of leakage in the late venous phase
Download (298KB)
4.
Fig. 3. Retinal fluorescein angiography data of the female patient with myelinated retinal fibers complicated by vascular abnormalities 3 months after intravitreal injection of ranibizumab (explanations in the text): a — fundus image; b–d — partial regression of the neovascularization and reduction of leakage
Download (290KB)
