Inactive macular neovascularization in Stargardt’s disease

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Abstract

The article describes a case report of bilateral inactive macular neovascularization in Stargardt’s disease in a young woman. The data of the ophthalmological examination, as well as those of the molecular genetic analysis are presented, the tactics of the patient’s care is discussed. No case report of the kind has been described in the literature previously, and therefore this one is of great interest.

About the authors

Pavel L. Volodin

S. Fyodorov Eye Microsurgery Federal State Institution

Email: volodinpl@mntk.ru
ORCID iD: 0000-0003-1460-9960

MD, Dr. Sci. (Med.), Professor, Head at the Retina Laser Surgery Department

Russian Federation, Moscow

Elena K. Pedanova

S. Fyodorov Eye Microsurgery Federal State Institution

Email: elenamntk@mail.ru
ORCID iD: 0000-0001-5191-3385
SPIN-code: 1409-0712

MD, Research Associate of the Retina Laser Surgery Department

Russian Federation, Moscow

Angelina D. Matyaeva

S. Fyodorov Eye Microsurgery Federal State Institution

Author for correspondence.
Email: matyaeva.lina@yandex.ru
ORCID iD: 0000-0001-7543-619X
SPIN-code: 3302-0808

Medical Resident

Russian Federation, Moscow

Mariya A. Poroshina

S. Fyodorov Eye Microsurgery Federal State Institution

Email: doctor_poroshina@mail.ru
ORCID iD: 0000-0002-3110-4772
SPIN-code: 8654-8948

Medical Resident

Russian Federation, Moscow

References

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  10. Japiassú RM, Moura Brasil OF, Maia HS, et al. Photodynamic therapy for bilateral and simultaneous choroidal neovascularization in Stargardt disease. Retin Cases Brief Rep. 2008;2(1):9–11. doi: 10.1097/ICB.0b013e3180467837
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  12. Querques G, Bocco MC, Soubrane G, Souied EH. Intravitreal ranibizumab (Lucentis) for choroidal neovascularization associated with Stargardt’s disease. Graefes Arch Clin Exp Ophthalmol. 2008;246(2):319–321. doi: 10.1007/s00417-007-0689-z
  13. Cheng JY, Adrian KH. Photodynamic therapy for choroidal neovascularization in Stargardt disease and retinitis pigmentosa. Retin Cases Brief Rep. 2009;3(4):388–390. doi: 10.1097/ICB.0b013e31817f2e3f
  14. Kim HH, Carvounis PE, Albini TA, et al. Photodynamic therapy for bilateral subfoveal choroidal neovascularization complicating stargardt macular dystrophy. Retin Cases Brief Rep. 2008;2(1):6–8. doi: 10.1097/ICB.0b013e318033907f
  15. Querques G, Sacconi R, Capuano V, et al. Treatment-naïve quiescent macular neovascularization secondary to AMD: The 2019 Young Investigator Lecture of Macula Society. Eur J Ophthalmol. 2021;31(6):3164–3176. doi: 10.1177/1120672120986370

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2. Fig. 1. Fundus photograph of the patient. In the macular area and along the arcades, there are bright spots with local pigmentation: a — right eye; b — left eye

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3. Fig. 2. Fundus autofluorescence of the patient. In the macular area and along the arcades, foci of increased autofluorescence (lipofuscin) correspond to bright spots in fig. 1: a — right eye; c — left eye. OCT: optically dense content in the fovea and parafovea (vitelliform material); destruction of the photoreceptor layer: b — right eye; d — left eye

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4. Fig. 3. OCT-A of patient. In the depth of the hyperreflective material, a network of pathological blood flow is determined: a, b — right eye; c, d — left eye

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