Retinal and choroidal circulation in patients with lattice retinal degeneration: optical coherence tomography-angiography study

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Abstract

BACKGROUND: There are insufficient data covering retinal and choroidal microcirculation in eyes with lattice retinal degeneration.

AIM: To investigate retinal and choroidal circulation in eyes with lattice retinal degeneration using optical coherence tomography-angiography (OCTA).

MATERIALS AND METHODS: The study included 10 patients with lattice retinal degeneration and 12 healthy individuals. All subjects underwent OCTA examination of the macula. Additionally, in four patients, OCTA within the area of lattice retinal degeneration was performed.

RESULTS: Retinal capillary non-perfusion, disorganization of retinal layers, a decrease of choriocapillaris perfusion, and choroidal thinning were found within the area of lattice degeneration in all cases. In the macula, the perfusion area in the choriocapillaris slab in the eyes with lattice degeneration and controls was 6.40 ± 0.21 and 6.19 ± 0.21 mm2 (p < 0.05), respectively. The number of flow voids in the choriocapillaris in the eyes with lattice degeneration and controls eyes was 40.6 ± 23.0 and 65.1 ± 25.7 (p < 0.05), respectively. The total area of flow voids in the choriocapillaris slab in the eyes with lattice degeneration and in controls eyes was 0.49 ± 0.04 and 0.54 ± 0.04 mm2 (p < 0.05), respectively.

CONCLUSIONS: The status the choroidal and choriocapillaris perfusion may play an important role in pathophysiology of the lattice retinal degeneration.

About the authors

Maria A. Burnasheva

Kirov Military Medical Academy

Email: maria.andreevna1@gmail.com
ORCID iD: 0000-0001-7384-2223
SPIN-code: 5574-3595

Cand. Sci. (Med.), Ophthalmologist, Ophthalmology Clinic

Russian Federation, Saint Petersburg

Dmitrii S. Maltsev

Kirov Military Medical Academy

Author for correspondence.
Email: glaz.med@yandex.ru
ORCID iD: 0000-0001-6598-3982
SPIN-code: 4903-2333

MD, Dr. Sci. (Med.), Head of Medical Retina Division, Professor of Prof. Volkov Department of Ophthalmology

Russian Federation, Saint Petersburg

Alexei N. Kulikov

Kirov Military Medical Academy

Email: alexey.kulikov@mail.ru
ORCID iD: 0000-0002-5274-6993
SPIN-code: 6440-7706

Dr. Sci. (Med.), Head of Prof. Volkov Department of Ophthalmology

Russian Federation, Saint Petersburg

References

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2. Fig. 1. Optical coherence tomography angiography imaging of lattice retinal degeneration and representative healthy region in the same eye: а — OCTA image shows retinal capillary non-perfusion; b — OCTA projection of choriocapillaris slab demonstrates decreased density of choriocapillaris and appearance of individual choriocapillary vessels; c — OCTA projection of full retina slab in healthy region shows normal retinal vascular pattern with low vessel density; d — OCTA projection of choriocapillaris slab in healthy region shows regular flow signal with indistinguishable individual vessels; e — сross-sectional OCT scan shows disorganization of retinal layers, retinal thinning, vitreoretinal traction (asterisk), and substantial choroidal thinning (arroheads); f — сross-sectional OCT scan in healthy region shows normal retinal structure and uninvolved choroid

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3. Fig. 2. Optical coherence tomography angiography (OCTA) imaging of choriocapillaris in normal retina and within lattice retinal degeneration: a — structural OCTA projection within unaffected retina; b — structural OCTA projection within small lattice retinal degeneration lesion; c — structural OCTA projection within large lattice retinal degeneration lesion; d — OCTA projection on choriocapillaris slab within unaffected retina; e — OCTA projection of choriocapillaris slab within small lattice retinal degeneration lesion shows individual vessels, decreased vessel density, and venous collectors (arrows); f — OCTA projection of choriocapillaris slab within large lattice retinal degeneration lesion shows individual vessels, decreased vessel density, and multiple venous collectors (arrows)

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4. Fig. 3. Choriocapillaris flow voids displayed with optical coherence tomography after applying Phansalkar autothresholding algorithm: a — choriocapillaris flow voids in eye with lattice retinal degeneration; b — choriocapillaris flow voids in eye of healthy individual

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Copyright (c) 2022 Burnasheva M.A., Maltsev D.S., Kulikov A.N.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


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