Study of the safety of long-term drainage of the suprachoroidal space with a polyurethane drainage tube (experimental study)

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Abstract

The article describes the results of an experimental study of the safety of long-term drainage of the suprachoroidal space (SCS) with a polyurethane drainage tube. The work was performed on 10 rabbits (20 eyes) of the Chinchilla breed, in which a polyurethane drainage tube was implanted in the SCS. The safety of the proposed method was assessed using histopathological examination, eye biomicroscopy, ophthalmoscopy, fluorescein angiography. The study results show the safety of the polyurethane tube presence in the suprachoroidal space for up to 30 days. At the same time, the presence of the polyurethane drainage tube in the SCS for more than 30 days leads to irreversible pathological changes of inner eye tunics.

About the authors

Alexey N. Kulikov

S.M. Kirov Military Medical Academy

Author for correspondence.
Email: alexey.kulikov@mail.ru
SPIN-code: 6440-7706

MD, PhD, DMedSc, Professor, Head of the Department. Ophthalmology Department

Russian Federation, Saint Petersburg

Sergey V. Sosnovskii

S.M. Kirov Military Medical Academy

Email: svsosnovsky@mail.ru
SPIN-code: 3058-7913

MD, Associate Professor of the Ophthalmology Department

Russian Federation, Saint Petersburg

Denis V. Shamrey

S.M. Kirov Military Medical Academy

Email: sham241@mail.ru

Ph.D, Lecturer, Department of Ophthalmology

Russian Federation, Saint Petersburg

Alexander S. Remigin

321 VKG

Email: aleksandrremigin@gmail.com

Head Resident, Ophthalmology Department

Russian Federation, Chita

Sergey I. Alekperov

State Research Institute of Military Medicine

Email: salekperov@rambler.ru

Deputy Head of Department

Russian Federation, Saint Petersburg

Alexey A. Suetov

State Research Institute of Military Medicine

Email: ophtalm@mail.ru

Head Researcher

Russian Federation, Saint Petersburg

Roman D. Berezin

S.M. Kirov Military Medical Academy

Email: berrom@yandex.ru

PhD., Department of Ophthalmology

Russian Federation, Saint Petersburg

Sergey V. Churashov

S.M. Kirov Military Medical Academy

Email: churashoff@mail.ru

Doctor of Medicine, Professor, Department of Ophthalmology

Russian Federation, Saint Petersburg

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Supplementary files

Supplementary Files
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1. JATS XML
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2. Fig. 1. Experimental animal (Chinchilla breed rabbit)

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3. Fig. 2. Polyurethane tubes TPM-U

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4. Fig. 3. “Mikmed-6” microscope (a) and photocamera TCA-5 (b)

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5. Fig. 4. Stages of polyurethane drainage tube implantation

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6. Fig. 5. Anterior segment of the experimental animal’s eye on Days 1-3 after surgery

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7. Fig. 6. Anterior segment of the experimental animal’s eye on Day 15 after surgery

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8. Fig. 7. Ophthalmoscopic findings on Day 1 (a) and Day 5 (b) after surgery

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9. Fig. 8. Fluorescein angiography on Day 20 after surgery: а – arteriovenous phase; b – venous recirculation phase

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10. Fig. 9. Gross specimen of the experimental animal’s eye (the arrow shows the site of polyurethane drainage tube exit through a sclerostomy)

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11. Fig. 10. Gross specimens of the eye fundus of experimental animals in the projection of a polyurethane drainage tube position (first control point of the study)

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12. Fig. 11. Microspecimens of inner eye tunics of experimental animals in the area of a polyurethane drainage tube position; SRF – subretinal fluid

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13. Fig. 12. Gross specimen of the eye fundus of experimental animals in the projection of a polyurethane drainage tube position (second control point of the study)

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14. Fig. 13. Microspecimens of inner eye tunics of an experimental animal in the area of a polyurethane drainage tube position; SRF – subretinal fluid; RPE – retinal pigment epithelium

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Copyright (c) 2018 Kulikov A.N., Sosnovskii S.V., Shamrey D.V., Remigin A.S., Alekperov S.I., Suetov A.A., Berezin R.D., Churashov S.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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