Subthreshold lasercoagulation (810 nm) for diabetic macular edema

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Abstract

Introduction. The threshold laser coagulation leads to irreversible damage of retinal structures, microscotomata appearance in the central visual field, contrast sensitivity decrease, and color vision impairment, being accompanied as well by the release of proinflammatory cytokines. For diabetic macular edema treatment, a method of high-density subthreshold laser coagulation (810 nm) was first developed, based on individualized choice of subthreshold parameters of laser irradiation, and permitting confluent application of laser impacts to the retina. Using multimodal diagnostic approach to the estimation of anatomic and functional treatment results, a minimally invasive character and safety of this DME treatment method were confirmed.

Purpose. The aim of this study was to comparatively evaluate the efficacy of a diode laser (810 mn) subthreshold laser treatment using high-density laser impact application in diode laser coagulation (DLC) and diode microphotocoagulation (DMP) modes.

Materials and methods. To compare the efficacy of subthreshold laser treatment methods (DLC and DMP), patients were divided into two groups, comparable in macular edema thickness and area. The first group (24 eyes) received a macular laser coagulation in grid pattern and MicroPulse diode laser (810 nm) regimen; biomicroscopically it was predominantly subthreshold high-density application of burns. The second group (29 eyes) received a macular laser coagulation in grid pattern and continuous diode laser (810 nm) regimen; biomicroscopically it was predominantly subthreshold high-density application of burns.

Results. After DLC and DMP, there was no statistically significant difference between compared groups in best corrected visual acuity. There was also no significant difference in retinal edema maximal height dynamics, retinal edema area, and central thickness in 2 and 4 months.

Conclusion. Subthreshold microphotocoagulation and laser coagulation methods at the same average power of laser exposure and other exposure parameters in the shortterm follow-up have comparable efficacy in the treatment of diabetic macular edema.

About the authors

Aleksandr S. Izmaylov

IR & TC “Eye Microsurgery” named after Academician S.N. Fyodorov, St. Petersburg Branch

Author for correspondence.
Email: 061@mail.ru

Doctor of Medical Science, MD of Highest Qualification, Head of Laser Surgery Department

Russian Federation, Saint Petersburg

Tat’yana V. Kotsur

IR & TC “Eye Microsurgery” named after Academician S.N. Fyodorov, St. Petersburg Branch

Email: tatiana781@yandex.ru

MD, Ophthalmologist. Laser Microsurgery and Fluorescent Angiography Department

Russian Federation, Saint Petersburg

References

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Supplementary files

Supplementary Files
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2. Fig. 1. Dynamics of the maximal retinal edema height after high-density microphotocoagulation and after high-density subthreshold laser coagulation: a – in 2 months; b – in 4 months

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3. Fig. 2. Dynamics of the central retinal thickness after high-density microphotocoagulation and after high-density subthreshold laser coagulation: a – in 2 months; b – in 4 months

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4. Fig. 3. Dynamics of the macular edema area after high-density microphotocoagulation and after high-density subthreshold laser coagulation: a – in 2 months; b – in 4 months

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5. Fig. 4. Angio-OCT results after high-density subthreshold laser coagulation: a – before treatment; b – in 1 month after treatment

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6. Fig. 5. Fluorescein angiography: a – before treatment (arteriovenous and late venous phases); b – in 1 month after subthreshold high-density laser coagulation

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Copyright (c) 2018 Izmaylov A.S., Kotsur T.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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