Possibilities of using cryotherapy in patients with ocular rosacea

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Abstract

Objective: to evaluate the clinical efficiency of eyelid cryotherapy with an autonomous titanium nicke lide cryoapplicator in patients with ocular rosacea regarding the dynamics of pro- and anti-inflammatory cytokines contents at local levels.

Materials and methods. 65 patients with ocular rosacea were observed. Depending on the therapy received, the patients were divided into two groups: in the main group, eyelid cryotherapy was applied for 2 weeks with an autonomous cryoapplicator made of porous-permeable titanium nickelide, and in the reference group, the patients received a traditional treatment for a month. The contents of cytokines (IL-1β, IL-8, IFN-α, IL-2, IL-10) in lachrymal fluid was evaluated by ELISA on Days 3, 7 and 30 after treatment.

Results. The opposite nature of cytokine balance changes and the ratio of its pro- and anti-inflammatory link during the follow-up period were revealed. A reliable dynamic increase of examined IFN-α and IL2 content in the lacrimal fluid after cryostimulation can evidence for an adequate activation of cellular immunity link, as well as for enhancement of regeneration mechanisms.

Conclusion. The analysis of obtained data evidences for a high efficiency of clinical and immunological effect of lid cryotherapy using titanium nickelide cryoprobe for ocular rosacea treatment.

About the authors

Marina M. Tlish

Kuban State Medical University

Author for correspondence.
Email: tlishmm@mail.ru

Doctor of Medical Science, Professor of Dermatovenerology Department

Russian Federation, Krasnodar

Natalya V. Kolesnikova

Kuban State Medical University

Email: troickaya@rambler.ru

Doctor of Biology Science, Professor, Department of Immunology, Allergology and Laboratory Diagnostics, Advanced Training Faculty

Russian Federation, Krasnodar

Viktor E. Gyunter

Research Institute of Shape Memory Material under Siberian Physico-Technical Institute and Tomsk State University

Email: 89138641814@mail.ru

Doctor of Technical Science, Professor, Honored Scientist of the Russian Federation, Director

Russian Federation, Tomsk

Aleksey N. Steblyuk

S.N. Fyodorov Eye Microsurgery Complex, Krasnodar Branch

Email: steblyuk@bk.ru

Candidate of Medical Science, Ophthalmologist, MD of Highest Qualification

Russian Federation, Krasnodar

Ekaterina S. Marchenko

Research Institute of Shape Memory Material under Siberian Physico-Technical Institute and Tomsk State University

Email: marchenko84@vtomske.ru

Candidate of Physical and Mathematical Sciences

Russian Federation, Tomsk

Marina E. Shavilova

Kuban State Medical University

Email: marina@netzkom.ru

Dermatovenerologist, Assistant, Dermatovenerology Department

Russian Federation, Krasnodar

Anna A. Tserkovnaya

Clinical Oncological Dispensary No. 1, Ministry of Public Health of Krasnodar Region

Email: 5247024@gmail.com

Oncologist

Russian Federation, Krasnodar, Russia

References

  1. Российское общество дерматовенерологов и косметологов. Федеральные клинические рекомендации. Дерматовенерология 2015: Болезни кожи. Инфекции, передаваемые половым путем. - М.: Деловой экспресс, 2016. [Rossiyskoe obshchestvo dermatovenerologov i kosmetologov. Federal’nye klinicheskie rekomendatsii. Dermatovenerologiya 2015: Bolezni kozhi. Infektsii, peredavaemye polovym putem. Moscow: Delovoy ekspress; 2016. (In Russ.)]
  2. Кубанова А.А., Махакова Ю.Б. Розацеа: распространённость, патогенез, особенности клинических проявлений // Вестник дерматологии и венерологии. - 2015. - № 3. - С. 36-45. [Kubanova AA, Makhakova YB. Rosacea: prevalence, pathogenesis, particular features of clinical manifestations. Vestn Dermatol Venerol. 2015;(3):36-45. (In Russ.)]
  3. Тлиш М.М., Поповская Е.Б., Сычёва Н.Л., и др. Сочетанная патология: клинические наблюдения // Вестник дерматологии и венерологии. - 2017. - № 4. - С. 66-73. [Tlish MM, Popovskaya EB, Sycheva NL, et al. Associated pathology: clinical оbservation. Vestn Dermatol Venerol. 2017;(4):66-73. (In Russ.)]
  4. Пуликов А.Е., Силина Л.В., Филиппенко Н.Г., Письменная Е.В. Офтальморозацеа как особая форма осложнённого течения розовых угрей // Научные ведомости Белгородского государственного университета. Серия: медицина, фармация. - 2012. - № 22-1. - С. 95-98. [Pulikov AE, Silina LV, Filippenko NG, Pis’mennaya EV. Oftal’morozatsea kak osobaya forma oslozhnennogo techeniya rozovykh ugrey. Belgorod State University scientific bulletin. Medicine, pharmacy. 2012;(22-1):95-98. (In Russ.)]
  5. Чехова Т.А., Черных В.В. Офтальморозацеа - этиология, патогенез, новые подходы к терапии // Офтальмохирургия. - 2016. - № 2. - С. 54-58. [Chekhova TA, Chernykh VV. Ophthalmic rosacea - etiology, pathogenesis, new approaches to the therapy. Ophthalmosurgery. 2016;(2):54-58. (In Russ.)]
  6. Кубанов А.А., Галлямова Ю.А., Гревцева А.С. Роль клещей Demodex в развитии папуло-пустулёзных дерматозов // Экспериментальная и клиническая дерматокосметология. - 2014. - № 2. - С. 43-46. [Kubanov AA, Gallyamova YA, Grevtseva AS. Role of Demodex mites in the development of papulopustular dermatoses. Eksperimental’naya i klinicheskaya dermatokosmetologiya. 2014;(2):43-46. (In Russ.)]
  7. Мельник Д.Д., Гюнтер В.Э., Дамбаев Г.Ц., и др. Медицинские материалы и имплантаты с памятью формы. Пористопроницаемые криоаппликаторы из никелида титана в медицине. - Томск: НПП МИЦ, 2010. [Mel’nik DD, Gyunter VE, Dambaev GT, et al. Meditsinskie materialy i implantaty s pamyat’yu formy. Poristo-pronitsaemye krioapplikatory iz nikelida titana v meditsine. Tomsk: NPP MITs; 2010. (In Russ.)]
  8. Mondal SK. Mucosa-associated lymphoid tissue lymphoma in conjunctiva. Indian J Pathol Microbiol. 2008;51(3):407-408. doi: 10.4103/0377-4929.42539.
  9. Nichols JE, Niles JA, Roberts NJ, Jr. Human lymphocyte apoptosis after exposure to influenza A virus. J Virol. 2001;75(13):5921-29. doi: 10.1128/JVI.73.13.5921-5929.2001.
  10. Вялов С.Л., Пшениснов К.П., Куиндоз Д. Современные представления о регуляции процесса заживления ран: обзор литературы // Анналы пластической, реконструктивной и эстетической хирургии. - 1999. - № 1. - С. 49-56. [Vyalov SL, Pshenisnov KP, Kuindoz D. Sovremennye predstavleniya o regulyatsii protsessa zazhivleniya ran: obzor literatury. Annaly plasticheskoy, rekonstruktivnoy i esteticheskoy khirurgii. 1999;(1):49-56. (In Russ.)]
  11. Маркелова Е.В., Кириенко А.В., Чикаловец И.В., Догадова Л.П. Характеристика системы цитокинов и её роль в патогенезе первичных глауком // Фундаментальные исследования. - 2014. - № 2. - С. 110-116. [Markelova EV, Kirienko AV, Chikalovets IV, Dogadova LP. Сharacteristic оf the cytokines system and its role in primary glaucoma pathogenesis. Fundamental research. 2014;(2):110-116. (In Russ.)]
  12. Бурилов К.Б., Костенёв С.В., Трунов А.Н. Оценка содержания провоспалительных цитокинов в слёзной жидкости после формирования роговичного клапана механическим микрокератомом и фемтосекундным лазером // Офтальмохирургия. - 2013. - № 4. - С. 34-37. [Burilov KB, Kostenev SV, Trunov AN. Assessment of the content of proinflammatory cytokines in lacrimal fluid after formation of corneal flap using mechanical microkeratome and femtosecond laser. Ophthalmosurgery. 2013;(4):34-37. (In Russ.)]
  13. Стеблюк А.Н., Колесникова Н.В., Гюнтер В.Э. Мониторинг цитокинового профиля влаги передней камеры глаза при хирургической обработке экспериментальных проникающих ран роговицы шовным материалом из никелида титана // Кубанский научный медицинский вестник. - 2014. - № 4. - С. 110-115. [Steblyuk AN, Kolesnikova NV, Gyunter VE. Monitoring of cytokine level moisture in aqueous chamber during surgical debridement of observational penetrating wounds of eye cornea with nickelid titanium suture material. Kubanskii nauchnyi meditsinskii vestnik. 2014;(4):110-115. (In Russ.)]
  14. Nishi O, Nishi K, Ohmoto Y. Effect of interleukin 1 receptor antagonist on the blood-aqueous barrier after intraocular lens implantation. Br J Ophthalmol. 1994;78(12):917-920. doi: 10.1136/bjo.78.12.885.

Supplementary files

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2. Fig. 1. Facial skin condition of Patient G., aged 58, with rosacea (a), and after 7 days of  cryotherapy treatment No. 10 (b)

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3. Fig. 2. Condition of cornea in Patient C., aged 24, with rosacea-keratitis before cryotherapy (a), and after the course of eyelid cryostimulation No. 10 (b)

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4. Fig. 3. Dynamics of IFN-α and IL-2 content in lacrimal fluid of patients with blepharitis 3 days (“Cryo-3”) and 30 days (“Cryo-30”) after cryotherapy and compared to conventional therapy (“CT-3”, “CT-30”)

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5. Fig. 4. Dynamics of IL-1, IL-10, and IL-8 contents in lacrimal fluid of patients with blepharitis 3 days (“Cryo-3”) and 30 days (“Cryo-30”) after cryotherapy and compared to conventional therapy (“CT-3, “CT-30”)

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Copyright (c) 2018 Tlish M.M., Kolesnikova N.V., Gyunter V.E., Steblyuk A.N., Marchenko E.S., Shavilova M.E., Tserkovnaya A.A.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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