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发表评论 Possibilities of using cryotherapy in patients with ocular rosacea
- 作者: Tlish M.1, Kolesnikova N.1, Gyunter V.2, Steblyuk A.3, Marchenko E.2, Shavilova M.1, Tserkovnaya A.4
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隶属关系:
- Kuban State Medical University
- Research Institute of Shape Memory Material under Siberian Physico-Technical Institute and Tomsk State University
- S.N. Fyodorov Eye Microsurgery Complex, Krasnodar Branch
- Clinical Oncological Dispensary No. 1, Ministry of Public Health of Krasnodar Region
- 期: 卷 11, 编号 4 (2018)
- 页面: 7-14
- 栏目: Articles
- URL: https://journals.rcsi.science/ov/article/view/11119
- DOI: https://doi.org/10.17816/OV1147-14
- ID: 11119
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详细
Objective: to evaluate the clinical efficiency of eyelid cryotherapy with an autonomous titanium nicke lide cryoapplicator in patients with ocular rosacea regarding the dynamics of pro- and anti-inflammatory cytokines contents at local levels.
Materials and methods. 65 patients with ocular rosacea were observed. Depending on the therapy received, the patients were divided into two groups: in the main group, eyelid cryotherapy was applied for 2 weeks with an autonomous cryoapplicator made of porous-permeable titanium nickelide, and in the reference group, the patients received a traditional treatment for a month. The contents of cytokines (IL-1β, IL-8, IFN-α, IL-2, IL-10) in lachrymal fluid was evaluated by ELISA on Days 3, 7 and 30 after treatment.
Results. The opposite nature of cytokine balance changes and the ratio of its pro- and anti-inflammatory link during the follow-up period were revealed. A reliable dynamic increase of examined IFN-α and IL2 content in the lacrimal fluid after cryostimulation can evidence for an adequate activation of cellular immunity link, as well as for enhancement of regeneration mechanisms.
Conclusion. The analysis of obtained data evidences for a high efficiency of clinical and immunological effect of lid cryotherapy using titanium nickelide cryoprobe for ocular rosacea treatment.
作者简介
Marina Tlish
Kuban State Medical University
编辑信件的主要联系方式.
Email: tlishmm@mail.ru
Doctor of Medical Science, Professor of Dermatovenerology Department
俄罗斯联邦, KrasnodarNatalya Kolesnikova
Kuban State Medical University
Email: troickaya@rambler.ru
Doctor of Biology Science, Professor, Department of Immunology, Allergology and Laboratory Diagnostics, Advanced Training Faculty
俄罗斯联邦, KrasnodarViktor Gyunter
Research Institute of Shape Memory Material under Siberian Physico-Technical Institute and Tomsk State University
Email: 89138641814@mail.ru
Doctor of Technical Science, Professor, Honored Scientist of the Russian Federation, Director
俄罗斯联邦, TomskAleksey Steblyuk
S.N. Fyodorov Eye Microsurgery Complex, Krasnodar Branch
Email: steblyuk@bk.ru
Candidate of Medical Science, Ophthalmologist, MD of Highest Qualification
俄罗斯联邦, KrasnodarEkaterina Marchenko
Research Institute of Shape Memory Material under Siberian Physico-Technical Institute and Tomsk State University
Email: marchenko84@vtomske.ru
Candidate of Physical and Mathematical Sciences
俄罗斯联邦, TomskMarina Shavilova
Kuban State Medical University
Email: marina@netzkom.ru
Dermatovenerologist, Assistant, Dermatovenerology Department
俄罗斯联邦, KrasnodarAnna Tserkovnaya
Clinical Oncological Dispensary No. 1, Ministry of Public Health of Krasnodar Region
Email: 5247024@gmail.com
Oncologist
俄罗斯联邦, Krasnodar, Russia参考
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