Donors of nitric oxide in the treatment of preeclampsia: influence on the state of the endothelium and hemodynamics in the functional mother-placenta-fetus system

We investigated influence of nitrovasodilators on functional status of endothelium in preeclampsia with measuring of thrombomodulin, sICAM-1 and sVCAM-1 plasma levels. Changes in feto-placental and uteroplacental hemodynamics were analysed after treatment with isosorbide mononitrate and isosorbide dinitrate. Our results showed efficacy of nitric oxide donors in complex therapy of preeclampsia.