Donors of nitric oxide in the treatment of preeclampsia: influence on the state of the endothelium and hemodynamics in the functional mother-placenta-fetus system

Elena A. Malakhovskaya; Малаховская Елена Алексеевна; Marina S. Zainulina; Зайнулина Марина Сабировна

doi:10.17816/JOWD88641

Donors of nitric oxide in the treatment of preeclampsia: influence on the state of the endothelium and hemodynamics in the functional mother-placenta-fetus system

Authors: Malakhovskaya E.A.¹, Zainulina M.S.¹
Affiliations:
1. State Medical University named after acad. I.P. Pavlova
Issue: Vol 53, No 4 (2004)
Pages: 42-45
Section: Original study articles
URL: https://journals.rcsi.science/jowd/article/view/88641
DOI: https://doi.org/10.17816/JOWD88641
ID: 88641

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Abstract

We investigated influence of nitrovasodilators on functional status of endothelium in preeclampsia with measuring of thrombomodulin, sICAM-1 and sVCAM-1 plasma levels. Changes in feto-placental and uteroplacental hemodynamics were analysed after treatment with isosorbide mononitrate and isosorbide dinitrate. Our results showed efficacy of nitric oxide donors in complex therapy of preeclampsia.