Dydrogesterone (duphaston) and its 20-dihydro- metabolite as selective modulators of estrogenic enzymes in human breast cancer cells

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Abstract

The presented data open up interesting prospects for studying the biological responses of progestogens in clinical trials in patients with breast cancer. Estradiol is one of the main factors that control the growth and development of breast cancer. Therefore, an important goal of research in recent years is to block the formation of estradiol inside cancer cells.

About the authors

Н. Н. Thole

Solvay Pharmaceuticals GmbH

Author for correspondence.
Email: info@eco-vector.com
Germany, Hanover

G. S. Chetrite

Institut de Puericulture

Email: info@eco-vector.com

Hormones & Cancer Research Unit

France, Париж

G. S. Philippe

Institut de Puericulture

Email: info@eco-vector.com

Hormones & Cancer Research Unit

France, Париж

J. R. Pasqualini

Institut de Puericulture

Email: info@eco-vector.com

Hormones & Cancer Research Unit

France, Париж

References

Supplementary files

Supplementary Files
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1. JATS XML
2. Fig. 1. The structure of progestogens: dydrogesterone and its metabolite 20-dihydro-dydrogesterone

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3. Fig. 3. The effect of dydrogesterone and its metabolite 20-dihydro-dydrogesterone on the conversion of estrone sulfate (E1S) to estradiol (E2) in hormone-dependent T-47D human breast cancer cell lines:

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4. Fig. 4. The effect of dydrogesterone and its metabolite 20-dihydro-dydrogesterone on the conversion of estrone (E1) to estradiol (E2) in hormone-dependent T-47D human breast cancer cell lines:

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