Premature rupture of membranes in preterm pregnancy: prediction of perinatal outcomes
- Authors: Kolyado O.V.1, Remnyova O.V.1, Korenovsky Y.V.1, Kobzeva D.A.2, Zharikova G.V.1, Suzopov E.V.1
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Affiliations:
- Altay State Medical University
- Altay Regional Clinical Perinatal Center
- Issue: Vol 71, No 1 (2022)
- Pages: 23-28
- Section: Original Research
- URL: https://journals.rcsi.science/jowd/article/view/66723
- DOI: https://doi.org/10.17816/JOWD66723
- ID: 66723
Cite item
Abstract
AIM: This study was aimed to determine predictors of severe lesions of the central nervous system in newborns from mothers with preterm labor complicated by premature rupture of membranes, and to develop a model for predicting adverse outcomes based on clinical data and biochemical markers.
MATERIALS AND METHODS: At the first, retrospective, stage of the study, in order to determine clinical predictors of severe cerebral injury, we studied anamnesis data and features of pregnancy and delivery in 101 patients with premature rupture of membranes, expectant management tactics and subsequent delivery at 26–33.6 weeks of gestation. At the second stage, in the prospective study, which included 33 patients, we evaluated the level of neuron-specific enolase in the amniotic fluid and determined its diagnostic significance as a predictor of severe lesions of the nervous system.
RESULTS: The following factors were determined as clinical predictors of severe cerebral ischemia in premature infants: delivery time, duration of the latency period, the proportion of stab leukocytes in the leukocyte formula, and the presence of funiculitis in the histological examination of the placenta. A prognostic model with sensitivity of 98% and specificity of 80%, including clinical predictors and neuron-specific enolase, was developed.
CONCLUSIONS: Prediction of severe cerebral ischemia and correction of the latency period allows for improving perinatal outcomes in premature infants and starting rehabilitation measures after birth in a timely manner.
Full Text
##article.viewOnOriginalSite##About the authors
Olga V. Kolyado
Altay State Medical University
Author for correspondence.
Email: kolyado.ov@gmail.com
ORCID iD: 0000-0002-5812-4925
MD
Russian Federation, 40, Lenin Ave., Barnaul, 656038Olga V. Remnyova
Altay State Medical University
Email: rolmed@yandex.ru
ORCID iD: 0000-0002-5984-1109
MD, Dr. Sci. (Med.), Professor
Russian Federation, 40, Lenin Ave., Barnaul, 656038Yury V. Korenovsky
Altay State Medical University
Email: timidin@gmail.com
ORCID iD: 0000-0002-4434-5217
MD, Cand. Sci. (Med.), Assistant Professor
Russian Federation, 40, Lenin Ave., Barnaul, 656038Darya A. Kobzeva
Altay Regional Clinical Perinatal Center
Email: d.antipova2406@mail.ru
ORCID iD: 0000-0001-8286-1450
MD
Russian Federation, BarnaulGanna V. Zharikova
Altay State Medical University
Email: ganna1704@mail.ru
ORCID iD: 0000-0002-3227-2348
Cand. Sci. (Biol.)
Russian Federation, 40, Lenin Ave., Barnaul, 656038Egor V. Suzopov
Altay State Medical University
Email: suzopov1egor@gmail.com
ORCID iD: 0000-0003-4730-5058
Scopus Author ID: 57191922248
Russian Federation, 40, Lenin Ave., Barnaul, 656038
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