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Post a Comment Lambert-Eaton myasthenic syndrome against the background of thyroid cancer: a clinical case
- Authors: Khozhenko E.V.1, Kiparisova E.S.1, Larina I.V.1, Vaulicheva A.L.1, Grigoriev S.S.1, Mavlyudova E.S.1
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Affiliations:
- Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies
- Issue: Vol 15, No 1 (2024)
- Pages: 107-112
- Section: Case reports
- URL: https://journals.rcsi.science/clinpractice/article/view/257942
- DOI: https://doi.org/10.17816/clinpract119952
- ID: 257942
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Abstract
BACKGROUND: Lambert–Eaton myasthenic syndrome (G73.1 according to ICD-10) is a rare autoimmune disease associated with a presynaptic impairment of neuromuscular transmission due to the production of antibodies to voltage-gated calcium channels. The peculiarity of Lambert–Eaton myasthenic syndrome is manifested in a combination of increased muscle weakness and fatigue with the phenomenon of «working in» — an increase in the muscle strength against the background of muscle load after a short-term maximum contraction. Lambert-Eaton myasthenic syndrome is often associated with small cell lung cancer and very rarely develops with tumors of another localization.
CLINICAL CASE DESCRIPTION: We observed an 80-year-old patient with complaints of weakness and pain in the hips, shoulders, pelvic region, and half-ptosis of the eyelids. For half-ptosis of the eyelids, a differential diagnosis was conducted with myasthenia gravis. Stimulation electromyography revealed the M-response increment, i.e. the phenomenon of “working in”, which is typical for this syndrome. The examination revealed papillary thyroid cancer, which was later treated surgically.
CONCLUSION: This case illustrates Lambert–Eaton’s paraneoplastic myasthenic syndrome, a rare tumor form associated with thyroid cancer.
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##article.viewOnOriginalSite##About the authors
Elena V. Khozhenko
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies
Author for correspondence.
Email: Choshenko@mail.ru
ORCID iD: 0000-0003-0313-1754
SPIN-code: 6347-9552
MD, PhD
Russian Federation, MoscowElena S. Kiparisova
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies
Email: kiparisova-es@yandex.ru
SPIN-code: 2841-9154
MD, PhD, Professor
Russian Federation, MoscowIraida V. Larina
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies
Email: Larina.iraida@yandex.ru
MD, PhD
Russian Federation, MoscowAlexandra L. Vaulicheva
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies
Email: Sandrals@mail.ru
Russian Federation, Moscow
Sergey S. Grigoriev
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies
Email: sscardiolog@gmail.com
Russian Federation, Moscow
Elvira S. Mavlyudova
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies
Email: elmav@mail.ru
Russian Federation, Moscow
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