INCREASED ACTIVITY OF ASPARTATE AMINOTRANSFERASE AND ALANINE AMINOTRANSFERASE AS A PREDICTOR OF POSTOPERATIVE PULMONARY EMBOLISM

Early diagnosis and prevention of pulmonary embolism is an urgent problem of modern medicine. Cancer patients have been described as a special group of the high risk for the development of this complication especially in the postoperative period. This article presents clinical observations of two patients with oncological pathology who had pulmonary embolism in the postoperative period. The diagnosis has been confirmed by CT angiography. The dynamics of transaminases activity in the postoperative period has been analyzed, certain regularities of their activity have been found, and the correlation of the obtained data with the links of the pathogenesis of pulmonary embolism has been studied. In the postoperative period there was a gradual increase of the activity of AST and ALT both no more than 5 times, then at the time of the appearance of clinical symptoms in the form of shortness of breath - a slight decrease in the activity of both indicators, followed by a sharp rise in activity. Probably such changes are associated with changes in pulmonary microcirculation, damage of the lung tissue cells. The study of the dynamics of AST and ALT activity in blood serum is an available method and is proposed as one of the ways of early diagnosis of pulmonary embolism.

pulmonary embolism, aspartate aminotransferase, alanine aminotransferase, postoperative period, oncology