APPLICATION OF VARIOUS MEANS OF STUDYING THE QUALITY OF LIFE TO ASSESS THE CONSTITUTIONAL SYMPTOMS OF MYELOPROLIFERATIVE NEOPLASMS

The chronic nature of the course, as well as the limited possibilities of specific therapy, determine the particular relevance of the use of quality of life assessment tools in planning the follow-up and treatment of patients with myeloproliferative neoplasms (MPN). Despite this, the issue of the lack of specific and sufficiently accurate methods for assessing the quality of life in patients with MPN remains unresolved. Currently, the MPN10 questionnaire is recommended for assessing symptoms in patients with MPN and symptoms of myelofibrosis. Given the low stage of validation in Russia and the narrow symptomatic focus of the questionnaire for a more complete and accurate assessment of the quality of life, it is recommended that it be used simultaneously with nosologically non-specific validated questionnaires. A comparative study of the effectiveness of various quality agents was conducted (SF-36, EQ-5D-5L, EORTC QLQ-C30, MPN-10), which revealed the relationship between the influence of constitutional symptoms and quality changes in patients with Ph-negative MPN (n = 20). The EQ-5D-5L questionnaire is the most sensitive tool for assessing the quality of life to the influence of constitutional symptoms of the disease. Thus, it is necessary to note the importance of using strictly specific tools for assessing the quality of life in relation to each nosological unit. However, the results of this study prove that changes in the quality of life in patients with Ph-negative MPN are not always due to the influence of constitutional symptoms. That is why the question of finding the most appropriate means of assessing the quality of life for this group of oncohematological diseases remains relevant. At the moment, for a more complete and accurate assessment of the quality of life of patients with Ph-negative MPN, simultaneous use of MPN-10 in combination with EQ-5D-5L is recommended.

EORTC QLQ-C30, EQ-5D-5L, SF-36, quality of life, Ph-negative myeloproliferative neoplasms, true polycythemia, essential plateletemia, primary myelofibrosis, quality of life assessment tools, MPN-10, EORTC QLQ-C30, EQ-5D-5L, SF-36