IMMUNOLOGICAL FEATURES OF YERSINIOUS COLITS AND INFLAMMATORY DISEASES OF THE INTESTINE. MECHANISM OF THEIR POSSIBLE ASSOCIATION

Nflammatory bowel disease (IBD) is a disease with not fully understood triggering factors. Lack of sufficient knowledge about the mechanisms of disease development inhibits the development of a scientifically based management strategy for patients with IBD. There is insufficient evidence of yersiniosis in IBD. In the course of work, the immunological features of IBD and infectious colitis caused by Y. pseudotuberculosis and Y. enterocolitica were studied. An analysis was made of the clinical and immunological features of UC, CD, and yersiniosis colitis based on the data from the case histories of two groups of patients. The work uses the results of an in-depth study of case histories of 78 patients with IBD. Data are presented on the presence of changes in the quantitative composition of Th2 lymphocytes, changes in the quantitative and qualitative composition of the intestinal microflora in patients with IBD. The inflammatory process after infectious colitis caused by Yersinia opens the door to the development of chronic inflammation, that is, the development of IBD. An analysis was made of the clinical and immunological features of UC, CD, and yersiniosis colitis based on the data from the case histories of two groups of patients. The results were compared with the analysis of scientific literature on the research topic. Among patients with IBD who have a history of the disease “yersiniosis colitis” (16 patients), only 10 have positive PCR results for intestinal yersiniosis. Thus, the development mechanism of IBD is a complex, multifaceted process, which involves many etiopathogenetic factors that overlap and complement each other.

MALDI-TOF, inflammatory bowel disease, intestinal yersiniosis, ulcerative colitis, PCR, MALDI-TOF, Th2 lymphocytes