Email this article EVALUATION OF LONG TERM RESULTS FOR AUTOLOGOUS TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS
- Authors: Sviridov A.A1, Bisaga A.G1
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Affiliations:
- S.M. Kirov Military Medical Academy of the Ministry of Defense
- Issue: Vol 39, No 1-1S (2020)
- Pages: 149-151
- Section: Articles
- URL: https://journals.rcsi.science/RMMArep/article/view/43395
- DOI: https://doi.org/10.17816/rmmar43395
- ID: 43395
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Abstract
The aim of the study was to analyze the long-term effictiveness of high-dose immunosuppressive therapy (HDIST) followed by autologous hematopoietic stem cell transplantation (AHSCT) in long-term observation (more than 20 years) of two MS patients. This therapy was performed for the first time in Russia at the S.M.Kirov Military Medical Academy. The therapy was carried out for the first time in Russia at the S.M. Kirov Military Medical Academy at the Department of Hematology and Clinical Immunology together with the Department of Nervous Diseases in 1999 and 2000. The research was carried out by long-term dynamic observation of changes in neurological status according to EDSS (Expanded Disability Status Scale), recording of disease exacerbations and control of brain magnetic resonance imaging (MRI) results. It has been established that as a result of conducting a HDIST with AHSCT, a record duration of more than twenty years of remission without any additional treatment is possible in comparison with other PITRS. At the same time, a high frequency of side effects was observed during the therapy. Thus, taking into account its high effictiveness, manifested as a regression of neurological symptoms and long-term long-term remission with no activity on MRI, HDIST with AHSCT is one of the promising methods of MS treatment. Significant frequency and severity of side effects requires further improvement of treatment technology as well as observation to assess the safety of this therapy.
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##article.viewOnOriginalSite##About the authors
A. A Sviridov
S.M. Kirov Military Medical Academy of the Ministry of DefenseSt. Petersburg, Russia
A. G Bisaga
S.M. Kirov Military Medical Academy of the Ministry of DefenseSt. Petersburg, Russia
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