POLYMORPHISM OF NITROGEN OXIDE SYNTHESIS GENES (NO), AS A PREDICTOR OF FORMATION OF CARDIO- VASCULAR PATHOLOGY

Spend a genetic analysis of the blood of 41 patients with using polymerase chain reaction (PCR) to detect the presence of a mutation in the nitric oxide synthase (NO) genes. All patients were clinically diagnosed with diseases of the cardiovascular system. Among the patietnts there are a part of them, based on an anamnesis, that have a relationship between the genetic predisposition and the presence of cardiovascular diseases which were also observed in parents and grandparents of the examined patients. During the study there were 2 polymorphic variants of genes of type III synthase nitric oxide (NOS3, endothelial or eNOS) - T786C and G894T. As a result there were revealed that 70% of the patients have a mutation of at least one of the polymorphic variants of the NOS3 genes and only 30% of the patients have a “ normal” allels, which indicates that there is a relationship between genetic mutations of nitric oxide synthase (NO) and an increased risk of developing diseases of the cardiovascular system in patients, in particular, such as neurocirculatory asthenia, hypertension, coronary heart disease. Besides there are a relationship between polymorphism of nitric oxide synthase genes (NOS3 or eNOS) and the risk of developing a pathology such as stroke, which is a prognostically unfavorable sign and it can lead to aggravation of concomitant diseases of the cardio-vascular system and the development of their complications, also it can lead to a decrease in the quality and life expectancy of patients. A decrease in the synthesis of nitric oxide (NO) affects the physiological properties of platelets which is manifested by a high risk of blood clots and an increase in mortality among patients.

nitric oxide synthase (NO), genetic analysis, mutations, gene polymorphism, relationship, risk, diseases of the cardiovascular system