COMPARATIVE EFFICIENCY OF ALLAPININ AND PROPANORM IN VENTRICULAR EXTRASISTOLIA IN PATIENTS WITH CORONARY HEART DISEASE

Ventricular extrasystoles is one of the most frequent arrhythmias in patients with coronary artery disease, and a progressive increase in the number of extrasystoles is associated with a risk of transformation of existing arrhythmias into life-threatening ventricular arrhythmias. The use of antiarrhythmic therapy helps to reduce their number and reduce the severity of symptoms. In order to study the effectiveness of propafenone and allapinin in patients with coronary artery disease, 28 men with "frequent" and "very frequent" ventricular extrasystoles were included in the study. The group of patients taking Allapinin at a dose of 75 mg/day included 12 people and the group taking Propanorm 450 mg/day - 16 people. After 1 month, Holter monitoring of the electrocardiogram was carried out: criteria for a positive antiarrhythmic effect in the form of a twofold reduction in extrasystoles were noted in 50% of patients in the allapinin group and in 56.3% in the propanorm group. Thus, in patients with coronary heart disease and frequent ventricular extrasystole, the use of class I antiarrhythmic drugs is accompanied by a positive result of antiarrhythmic therapy.

ventricular extrasystoles, coronary heart disease, antiarrhythmic therapy, allapinin, propanorm, daily Holter ECG monitoring