STUDYING THE ROLE OF MELATONIN AND CHRONIC INFLAMMATION IN THE DEVELOPMENT AND PROGRESSION OF THE METABOLIC SYNDROME IN YOUNG PEOPLE

A single-center observational study was conducted of 95 people who were examined at the clinic of military field therapy of the S. Kirov Military Medical Academy and the St. Petersburg National Research Academic University of the Russian Academy of Sciences. Two groups were formed: the control (n = 46) - practically healthy young men and the studied (n = 49) - young men with metabolic syndrome. Based on the results of laboratory and instrumental studies, a comparative analysis of the level of 6-COMT, markers of chronic inflammation, data of biochemical and general clinical blood tests between the studied groups, as well as a correlation analysis between the studied indicators of 6-COMT of the day and night fractions were carried out. A 2-fold decrease in the level of 6-COMT was found in young people with metabolic syndrome, an increase in the level of pro-inflammatory cytokines (IL-1, IL-6, TNF-α) and a decrease in anti-inflammatory cytokines (IL-4 and IL-10) in the study groups, in comparison with almost healthy young men. Consequently, the metabolic syndrome in young people is associated with the presence of latent sluggish inflammation due to the low concentration of melatonin in the blood, and, consequently, a decrease in its anti-inflammatory function. The scientific novelty of this study is to determine the importance of the influence of melatonin in the development and progression of the metabolic syndrome and chronic sluggish inflammatory process, which are modulated factors of cardiovascular diseases. The scientific and practical significance of this study is to determine the role of melatonin as a factor that initiates obesity and the accompanying inflammatory process in young people.

metabolic syndrome, obesity, melatonin, chronic inflammation, young men, 6-COMT, pro-inflammatory cytokines, anti-inflammatory cytokines, antioxidants