COMPARATIVE ASSESSMENT OF LEVELS OF ANTIBODIES TO ANTIGENS USED TO VACCINATE PLASMA DONORS FOR FRACTIONATING

Aim. The aim of the study was to compare the level of antibodies to antigens, which were used for vaccination, and those to foreign vaccine antigens among donors immunized with different vaccines. Materials and methods. The prevaccinal examination of 9459 plasma donors for fractionating during the period from 2008 to 2011 (donors aged18-60) included determination of blood serum AB to tetanus anatoxin (TA). The level of specific antibodies to tetanus anatoxin was assessed using assay kit for detection of antitoxic diphtheria and tetanic antibodies “IFA anti DS” (SPA “Microgen”, Perm). To carry out donors’ immunization, tetanus anatoxin - refined, adsorbed, liquid for donors (NPU “Microgen”, Perm) was used. Results. Changes in immune response of donors (who had in anamnesis immunizations with vaccines against TBE) were found in case of subsequent immunizations with TA for donors, that is, increase in AB production not only with TA for donors, but as a whole. A high degree of linear correlation between increase in production of AB to tetanus toxin and tick-borne encephalitis vaccine ( r = 0,73) was revealed. Conclusions. It is recommended to carry out tetanus anatoxin immunization of donors, earlier immunized with tick-borne encephalitis vaccine, in the intervals between remote revaccinations that will permit to use immune donor plasma more rationally, and if necessary, to use it for production of the other types of directed immunoglobulins.

Specific immunoglobulins, immunity, postvaccinal antibodies