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Post a Comment Diagnostics and correction of microcirculation disorders and endothelial dysfunction in complex therapy of acute pancreatitis with antioxidant drugs
- Authors: Samartsev V.A.1, Gavrilov V.A.1, Podtaev S.Y.2, Pushkarev B.S.1, Domrachev A.A.1, Sidorenko A.Y.3
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Affiliations:
- E.A. Vagner Perm State Medical University
- SC “FM Diagnostics”
- City Clinical Hospital № 4
- Issue: Vol 39, No 3 (2022)
- Pages: 63-72
- Section: Methods of diagnosis and technologies
- URL: https://journals.rcsi.science/PMJ/article/view/106078
- DOI: https://doi.org/10.17816/pmj39363-72
- ID: 106078
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Abstract
Objective. To assess the efficiency of using polypositional skin thermometry of high resolution with wavelet-analysis of the obtained curve as a screening noninvasive method for diagnostics and correction of microcirculatory disorders and endothelial dysfunction in complex therapy of acute pancreatitis using antioxidant drugs.
Materials and methods. A prospective open randomized study of 30 patients with acute pancreatitis was carried out. The polypositional skin thermometry of high resolution with wavelet-analysis of the obtained curve was chosen as a screening method of diagnostics of microcirculatory disorders and endothelial dysfunction. Measurement of temperature oscillation amplitude with an accuracy to 0,001 °С was performed in conditions of skin heating with index finger. The study was implemented before and after calf blood deproteinized hemoderivative infusion.
Results. Reliable changes in skin temperature oscillation of the microcirculatory bed of the skin in the endothelial range on the days 1, 2 and 3 of drug infusion were detected. In the investigated group of patients, the phenomena of transitory organ dysfunction were arrested during 48 hours that proves the presence of pancreatitis of a moderate degree of severity. The temperature oscillation amplitudes of skin in neurogenic range significantly differed by the moment of arresting organ dysfunction.
Conclusions. The method of polypositional skin thermometry of high resolution with wavelet-analysis of the obtained curve can be offered as an instrument for assessment of endothelial dysfunction prior to appearance of clinical manifestations of acute pancreatitis. The calf blood deproteinized hemoderivative infusions applied as a metabolic therapy positively influence the endothelial dysfunction in acute pancreatitis of a moderate degree of severity.
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##article.viewOnOriginalSite##About the authors
Vladimir A. Samartsev
E.A. Vagner Perm State Medical University
Email: inmyplay@mail.ru
MD, PhD, Professor, Head of Department of General Surgery №1
Russian Federation, PermVasilii A. Gavrilov
E.A. Vagner Perm State Medical University
Email: inmyplay@mail.ru
ORCID iD: 0000-0002-1950-065X
https://hirurgperm.ru/
Candidate of Medical Sciences, Associate Professor, Department of General Surgery №1
Russian Federation, PermSergei Yu. Podtaev
SC “FM Diagnostics”
Email: inmyplay@mail.ru
Director for Scientific Research
Russian Federation, PermBoris S. Pushkarev
E.A. Vagner Perm State Medical University
Email: inmyplay@mail.ru
surgeon, postgraduate student, Department of General Surgery №1
Russian Federation, PermAndrei A. Domrachev
E.A. Vagner Perm State Medical University
Email: inmyplay@mail.ru
resident, Department of General Surgery №1
Russian Federation, PermAnastasiia Yu. Sidorenko
City Clinical Hospital № 4
Author for correspondence.
Email: inmyplay@mail.ru
surgeon
Russian Federation, PermReferences
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