Antioxidant status of patients with atherothrombotic variant of ischemic stroke

Aim. To study the dependence of antioxidant status (AOS) on the age, sex, localization and size of the damage focus in patients during the most acute period of the development of atherothrombotic variant of ischemic stroke.

Materials and methods. Seventy four patients (main group) in the most acute period of atherothrombotic variant of ischemic stroke were examined. The group of comparison, comparable by age and sex, included 15 healthy persons. The total blood serum antioxidant status was investigated using an assay kit of “Vector-Best” Company B-7501 (“Vector-Best”, Russia).

Results. AOS value in the comparison group was 1,69 ± 0,17 mmol/l (median 1,72; interquartile range 1,53-1,83 mmol/l) that corresponded to the standard interval, indicated in the assay kit guidelines (1,3-1,8 mmol/l). OAS did not differ in men and women (criterion U = 26,0; p = 0,816). In patients of the main group, AOS was reduced ( p = 0,000034); AOS value was 1,14 ± 0,4 mmol/l (median 1,12 mmol/l, interquartile range 0,81-1,45 mmol/l). Age, sex and localization of stroke focus did not reliably influence the degree of AOS fall. Moderate reverse correlation between the focal sizes and decreased AOS value was established. Spearman’s rank correlation coefficient was -0,79 ( p < 0,001).

Conclusions. Decrease in AOS during the most acute period of developing atherothrombotic stroke does not depend on sex, age, ischemic focus localization, but it depends on sizes of the focus, subjected to ischemization.