Normal concentration of oral fluid procalcitonin and concentration in periodontitis
- Authors: Gileva O.S.1, Mandra Y.V.2, Sivak E.Y.1, Polushina L.G.2, Libik T.V.1, Мaksimova A.Y.2, Sosnin D.Y.1
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Affiliations:
- E.A. Vagner Perm State Medical University
- Ural State Medical University
- Issue: Vol 38, No 4 (2021)
- Pages: 62-69
- Section: Original studies
- URL: https://journals.rcsi.science/PMJ/article/view/77934
- DOI: https://doi.org/10.17816/pmj38462-69
- ID: 77934
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Abstract
Objective. To study the procalcitonin concentration (PCC) in the oral fluid of healthy persons and patients with periodontitis.
Materials and methods. The procalcitonin concentration was studied in the oral cavity of 42 patients with periodontitis (main group) and 25 patients with sanitized oral cavity (comparison group).
Results. The result medians in the comparison group by 1.658 times exceeded the median in the main group (р = 0,004315) and made up for the main group 114 (64; 144) pg/ml and for the comparison group 189 (117; 485) pg/ml. No differences in the oral fluid PCC concentration between men and women (p = 0,052) were revealed. There was not observed the dependence of the PCC content in the saliva on the age of the examined persons (R = –0.208).
Conclusions. The decrease in the oral fluid PCC concentration can be induced by the decrease in the bacterial load due to preliminary sanation of the oral cavity and dilution of the saliva as a result of activation of exudation and salivation processes in periodontium tissue inflammation.
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##article.viewOnOriginalSite##About the authors
O. S. Gileva
E.A. Vagner Perm State Medical University
Email: sosnin_dm@mail.ru
ORCID iD: 0000-0002-4289-6285
Scopus Author ID: 6602237829
MD, PhD, Professor, Head of Department of Therapeutic Dentistry and Propaedeutics of Dental Diseases
Russian Federation, PermYu. V. Mandra
Ural State Medical University
Email: sosnin_dm@mail.ru
ORCID iD: 0000-0002-8439-3272
MD, PhD, Professor, Professor of Department of Therapeutic Dentistry and Propaedeutics of Dental Diseases
Russian Federation, EkaterinburgE. Yu. Sivak
E.A. Vagner Perm State Medical University
Email: sosnin_dm@mail.ru
ORCID iD: 0000-0002-8739-0245
Candidate of Medical Sciences, Associate Professor, Department of Therapeutic Dentistry and Propaedeutics of Dental Diseases
Russian Federation, PermL. G. Polushina
Ural State Medical University
Email: sosnin_dm@mail.ru
Candidate of Medical Sciences, researcher, Central Research Laboratory
Russian Federation, EkaterinburgT. V. Libik
E.A. Vagner Perm State Medical University
Email: sosnin_dm@mail.ru
ORCID iD: 0000-0002-9790-6700
Candidate of Medical Sciences, Associate Professor, Department of Therapeutic Dentistry and Propaedeutics of Dental Diseases
Russian Federation, PermA. Yu. Мaksimova
Ural State Medical University
Email: sosnin_dm@mail.ru
postgraduate student, Department of Clinical Laboratory Diagnostics and Bacteriology, chief researcher of Central Research Laboratory
Russian Federation, EkaterinburgD. Yu. Sosnin
E.A. Vagner Perm State Medical University
Author for correspondence.
Email: sosnin_dm@mail.ru
ORCID iD: 0000-0002-1232-8826
MD, PhD, Associate Professor, Department of Clinical Laboratory Diagnostics
Russian Federation, PermReferences
- Gileva O.S., Bondarenko E.A., Gibadullina N.V., Sadilova V.A., Gileva E.S., Pozdnjakova A.A., Satjukova LJa. New approaches to the treatment of inflammatory periodontal diseases. Ural'skij medicinskij zhurnal 2011; 5 (83): 22–27 (in Russian).
- Nazir M., Al-Ansari A., Al-Khalifa K., Alhareky M., Gaffar B., Almas K. Global Prevalence of Periodontal Disease and Lack of Its Surveillance. Scientific World Journal 2020; 2020; 2146160.
- Mariotti A., Hefti A.F. Defining periodontal health. BMC Oral Health 2015; 15: 1, 6.
- Bazarnyi V.V., Polushina L.G., Maksimova A.Yu., Svetlakova E.N., Sementsova E.A., Nersesyan P.M., Mandra Yu.V. Use of integral indices in the evaluation of buccal cytogram in normal and oral pathology. Klinicheskaya laboratornaya diagnostika 2019; 64 (12): 736–739 (in Russian).
- Sosnin D.Yu., Gileva O.S., Sivak E.Yu., Daurova F.Yu., Gibadullina N.V., Korotin S.V. The content of vasculoendothelial growth factor in saliva and serum in patients with periodontitis. Klinicheskaja laboratornaja diagnostika 2019; 64 (11): 663–668 (in Russian).
- Jiang H., Zhang Y., Xiong X., Harville E.W., Qian X. Salivary and serum inflammatory mediators among pre-conception women with periodontal disease. BMC Oral Health 2016; 16 (1): 131.
- Jasim H., Carlsson A., Hedenberg-Magnusson B., Ghafouri B., Ernberg M. Saliva as a medium to detect and measure biomarkers related to pain. Sci Rep 2018; 8 (1): 3220.
- Khurshid Z., Zohaib S., Najeeb S., Zafar M.S., Slowey P.D., Almas K. Human Saliva Collection Devices for Proteomics: An Update. Int J Mol Sci 2016; 17 (6): 846.
- Sivak E.Yu., Sosnin D.Yu., Gileva O.S., Muhamadeev I.S., Maksudova A.A. Proteome of mixed saliva in patients with chronic generalized periodontitis on the background of carotid artery stenosis. Stomatologija 2019; 1: 38 (in Russian).
- Galhardo L.F., Ruiv G.F., de Oliveira L.D., Parize G., Soléo Ferreira Dos Santos S., Pallos D., Leão M.V.P. Inflammatory Markers in Saliva for Diagnosis of Sepsis in hospitalized patients: A Cross-Sectional Study. European Journal of Clinical Investigation 2020; 50 (5): e13219.
- Patel N., Belcher J., Thorpe G., Forsyth N.R., Spiteri M.A. Measurement of C-reactive protein, procalcitonin and neutrophil elastase in saliva of COPD patients and healthy controls: correlation to self-reported wellbeing parameters. Respir Res 2015; 16 (1): 62.
- Sravya M.V.N., Koduganti R.R., Panthula V.R., Surya P.J., Gireddy H., Dasari R., Ambati M. Efficacy of an herbal antioxidant as an adjunct to nonsurgical periodontal therapy on procalcitonin levels in smokers with chronic periodontitis. J Indian Soc Periodontol 2019; 23 (5): 430–435.
- Bassim C.W., Redman R.S., DeNucci D.J., Becker K.L., Nylen E.S. Salivary Procalcitonin and Periodontitis in Diabetes. Journal of Dental Research 2008; 87(7): 630–634.
- Hendek M.K., Erdemir E.O., Kisa U. Evaluation of Salivary Procalcitonin Levels in Different Periodontal Diseases. Journal of Periodontology 2015; 86 (6): 820–826.
- Redman R.S., Kerr G.S., Payne J.B., Mikuls T.R., Huang J., Sayles H.R., Becker K.L., Nylén E.S. Salivary and serum procalcitonin and C-reactive protein as biomarkers of periodontitis in United States veterans with osteoarthritis or rheumatoid arthritis. Biotech Histochem 2016; 91(2): 77–85.
- Yousefimanesh H., Robati M., Malekzadeh H., Jahangirnezhad M., Ghafourian Boroujerdnia M., Azadi K. Investigation of The Association between Salivary Procalcitonin Concentration and Chronic Periodontitis. Cell J 2015; 17(3): 559–563.