INFLUENCE OF BRAIN-SPECIFIC PROTEIN S-100 AND ENDOTHELIAL NO-SYNTHASE ANTIBODIES-CONTAINING DRUG ON DEGREE OF ANXIOUS-DEPRESSIVE DISORDERS IN PATIENTS WITH ISCHEMIC STROKE IN EARLY REHABILITATION PERIOD

Aim. To estimate the dynamics of asthenic and anxious-depressive disorders in the early rehabilitation period of ischemic stroke against the background of taking a drug, containing antibodies to brain-specific protein S-100 and endothelial NO-synthase. Materials and methods. Sixty five patients (45 men and 20 women) with a mean age of 63.5 ± 5.3 years were examined in the early rehabilitation period of ischemic stroke. Neuropsychological examination inclu-ded the following tests: subjective multidimentional fatigue inventory (MFI-20), hospital anxiety and depression scale (HADS), National Institute of Health Stroke Scale (NIHSS). Results. After a course of taking a drug, containing antibodies to brain-specific protein S-100 and endothelial NO-synthase, manifestation of asthenia reduced in the main group by 35.48 %, p < 0.05, in the group of compari-son - by 9.57 %; anxious-depressive symptomatology decreased by 26.91 %, p < 0.05 and 5.16 %, respectively. Conclusions. Against the background of taking a brain-specific protein S-100 and endothelial NO-synthase antibodies-containing drug in the dose of 0.036 g, patients of the main group demonstrated faster regression of asthenic, anxious-depressive symptomatology and reduction of neurological deficiency manifestation.

Ischemic stroke, early rehabilitation period, asthenic disorders, anxious-depressive symptomatology, antibodies to brain-specific protein S-100 and endothelial NO-synthase