PECULIARITIES OF GANGLIONIC CONDUCTION OF EXCITATION AFTER DEPANCREATIZATION

Aim. To study the vegetative ganglion function after partial ablation of the pancreas. Materials and methods. Electrical activity of the postganglionic trunk fibers of the upper cervical sympathetic ganglion, with preganglionars stimulated by the rectangular impulse of supramaximal strength of 0,5 msec duration, was studied on 42 animals in the control and after depancreatization. Acetylcholine (AC) content in the ganglion before and after partial depancreatization, excitation conduction velocity by preganglionic fibers, amplitude and duration of postganglionic fibers action potential (AP), lability with stimulation of 10-40 Hz, posttetanic potentiation (PTP) was investigated. To assess the reliability of differences, Student’s t test was used. Critical significance level when controlling statistical hypotheses was accepted as equal to 0,05. Results. Ganglionic acetylcholine content on the day 9 after pancreatectomy decreased by three times. It was accompanied by the reduction of velocity of excitation spreading along the preganglionic fibers of the upper cervical sympathetic ganglion. Simultaneously, growth of latent period duration and postganglionic trunk action potential was registered. Development of pessimum with stimulation frequency of 20-40 Hz is significantly quickened, but posttetanic potentiation, typical for ganglion, completely disappears and is changed by the posttetanic depression. It proves fall in lability and functional properties of vegetative ganglion in the operated animals. Conclusions. Introduction of acetylcholine and lipocaic fully or partially compensated the occurring impairment of ganglionic conduction of excitation.

Upper cervical sympathetic ganglion, acetylcholine synthesis, pancreatectomy