PREDICTION OF COLORECTAL ANASTOMOSIS FAILURE

Aim. To study the possibilities of using chemiluminescent blood analysis and determining blood plasma lactate content for prediction of colorectal anastomosis failure. Materials and methods. Chemoluminescent blood analysis was carried out and blood plasma lactate content was determined within the days 1, 4 and 8 after the surgery in 78 patients with colorectal cancer, who had undergone the radical surgical intervention. Blood of 10 donors was used as a control. All patients were divided into 2 groups. Group I included 5 patients with interintestinal anastomosis failure developed, group II included the rest 73 persons. Results. Before the treatment started, a reliable elevation of chemiluminescence intensity was revealed in patients with colorectal cancer. Within the days 1 and 4 after the surgery, chemiluminescence indices were significantly higher in the group of patients with anastomosis failure than in patients of the second group. By the postoperative day 8, patients of group II experienced normalization of chemiluminescence indices, whereas in patients with anastomosis failure these indices remained reliably increased. Within the postoperative days 1 and 4, blood plasma lactate content significantly raised in patients of group I. No changes in lactate level among patients with uncomplicated postoperative course were noted. Conclusions. Chemiluminescent erythrocyte analysis and determination of blood plasma lactate content within the postoperative day 1 can be used to predict colorectal anastomosis failure in patients with malignant neoplasms of the colon.

Colorectal cancer, chemiluminescent blood analysis, predicted complications