Experience of managing neonates and breastfed in-fants with grade IV bilateral hydronephrosis

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Abstract

To analyze the clinical cases of four patients with grade IV bilateral hydronephrosis. Ultrasound examination of the urinary system was used as the main examination method. During the first stage of surgical treatment, all children underwent preliminary urinary diversion; a month later, the results were assessed. The result of the preliminary urinary diversion was the implementation of the Heines-Andersen-Kucher reconstructive operation. According to the control ultrasound performed a month after the nephrostomy, pelvis on the nephrostomy was reduced in all cases, parenchyma thickness increased by an average of 4.5 times, improvement in intragranular blood flow was noted. Evaluation of the effectiveness of pyeloplasty was carried out according to three criteria: restoration of urodynamics, restoration of kidney function and the presence of infectious complications. The parenchyma of the operated kidney grew by an average of 3 times, the pelvis decreased by an average of 3.5 times. Restoration of intrarenal blood flow to the cortical layer, inclusive, was noted in 5 of 8 renal units. Before pyeloplasty, there were marked changes in the renal parenchyma and a decrease in its function by an average of 34 ± 14 %; a year after reconstructive surgery, the changes became moderate, there was an improvement in renal function, a decrease in function by 25 ± 10 %. In our opinion, the starting method for providing urgent surgical care to neonates and breastfed infants with grade IV GN is preliminary urinary diversion, which allows us to determine the functional reserve of the renal parenchyma, delay reconstructive surgery, thereby giving time for the restoration of renal function and avoiding organ-carrying surgery.

About the authors

S. N. Nikolaev

Russian National Research Medical University named after N.I. Pirogov; Children's City Clinical Hospital named after N.F. Filatov

Email: ss181219@mail.ru

MD, PhD, pediatric surgeon of Highest Qualification Category, Head of Center of Urology and Reproductive Health, Professor of Department of Pediatric Surgery

Russian Federation, Moscow

S. V. Sergeeva

Russian National Research Medical University named after N.I. Pirogov

Author for correspondence.
Email: ss181219@mail.ru
ORCID iD: 0000-0003-1602-988X

pediatric surgeon, postgraduate student, Department of Pediatric Surgery

Russian Federation, Moscow

L. B. Menovshchikova

Russian National Research Medical University named after N.I. Pirogov; Children's City Clinical Hospital named after N.F. Filatov

Email: ss181219@mail.ru

MD, PhD, pediatric surgeon of Highest Qualification Category, pediatric urologist-andrologist, Professor of Department of Pediatric Surgery

Russian Federation, Moscow

M. V. Levitskaya

Children's City Clinical Hospital named after N.F. Filatov

Email: ss181219@mail.ru

Candidate of Medical Sciences, pediatric surgeon of Highest Qualification Category, Neonatal and Preterm Infants Unit

Russian Federation, Moscow

V. S. Shumikhin

Russian National Research Medical University named after N.I. Pirogov; Children's City Clinical Hospital named after N.F. Filatov

Email: ss181219@mail.ru

Candidate of Medical Sciences, pediatric surgeon of Highest Qualification Category, Head of Neonatal and Preterm Infants Unit, Associate Professor of Department of Pediatric Surgery

Russian Federation, Moscow

N. O. Erokhina

Children's City Clinical Hospital named after N.F. Filatov

Email: ss181219@mail.ru

pediatric surgeon, Neonatal and Preterm Infants Unit

Russian Federation, Moscow

A. G. Burkin

Children’s City Clinical Hospital named after Z.A. Bashlyaeva

Email: ss181219@mail.ru

Candidate of Medical Sciences, pediatric urologist-andrologist, Head of Pediatric Urology-Andrology and Planned Surgery Unit

Russian Federation, Moscow

References

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  2. Pavlova V.S., Kryuchko D.S., Podurovskaya Yu.L., Pekareva N.A. Congenital anomalies of the kidney and urinary tract: an analysis of modern diagnostic principles and prognostically significant markers of renal tissue damage. Neonatology: News, Opinions, Training 2018; 6 (2): 78–86 (in Russian).
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  4. Yuliaa A., Winyarda P. Management of antenatally detected kidney malformations. Early Human Development 2018; 126: 38–46.
  5. Onen A. An alternative grading system to refine the criteria for severity of hydroneprosis and optimal treatment guidelines in neonates with primary UPJ-type hydroneprosis. J Pediatr Urol 2007; 3 (3): 200–205.
  6. Braga L., McGrath M., Farrokhyar F., Jegatheeswaran K., Lorenzo A. Associations of Initial Society for Fetal Urology Grades and Urinary Tract Dilatation Risk Groups with Clinical Out-comes in Patients with Isolated Prenatal. The journal of urology 2017; 197: 831–837.
  7. Babu R., Vittalraj P., Sundaram S., Manjusha M.P., Ramanan V., Sai V. Comparison of different pathological markers in predicting pyeloplasty out-comes in children. Journal of Pediatric Surgery 2019; 55 (8): 1–5.

Supplementary files

Supplementary Files
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2. Figure 1. Ultrasound of the kidneys of the fetus at 34 weeks of gestation in B-mode

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3. Figure 2. Intraoperative picture. Laparoscopic approach. Stenotic pyelourethral segment. JJ stent does not pass the stenotic zone

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4. Figure 3. Dynamics of the increase in the thickness of the parenchyma and contraction of the PAP of the renal pelvis before nephrostomy and in the follow-up

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5. Figure 4. Pyelourethral segment. Masson's stain with aniline blue. Magnification × 10. Hypoplasia and randomness of myocytes

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Copyright (c) 2021 Nikolaev S.N., Sergeeva S.V., Menovshchikova L.B., Levitskaya M.V., Shumikhin V.S., Erokhina N.O., Burkin A.G.

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This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
 


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