BLOOD ADIPOKINES DYSBALANCE IN PREGNANT WOMEN WITH OBESITY

Aim. To assess the blood serum adipokine content in pregnant women with obesity of different type and degree. Materials and methods. Leptin, resistin, adiponectin content was studied in the blood serum of 65 pregnant women with obesity. Results. Among pregnant women with obesity, the number of pregnancy, labour and postnatal complications is significantly higher, the newborn health status is worse. Blood serum leptin content in pregnant women with obesity by 4 times exceeded the content of this hormone in healthy pregnant women. In the blood serum of pregnant women with android obesity, decrease in adiponectin (4,18 ± 0,39 mkg/ml) content as compared to patients with gynoid obesity (8,70 ± 0,55 mkg/ml) was revealed. Reliable rise in blood serum resistin level among pregnant women with obesity (9,8 ± 0,83 ng/ml) versus pregnant women with normal body mass(6,28 ± 0,6 ng/ml) was found. Conclusions. Direct correlation dependence between the body mass and the leptin content was registered that indicates compensatory stimulation of this hormone production by placenta for the prevention of hypoxia and fetoplacental insufficiency development. Decrease in the level of adiponectin and rise in the level of resistin among pregnant women with android obesity cause the development of gestation diabetes mellitus and formation of mother’s and fetal complications.

Adipokines, pregnancy, obesity