RISK FOR DEVELOPMENT OF ACUTE GASTRIC AND DUODENAL ULCERS IN TREATMENT OF PYO-INFLAMMATORY DISEASES OF SOFT TISSUES USING NONSTEROID ANTI-INFLAMMATORY DRUGS

Aim. To carry out the comparative characteristic of anti-inflammatory drugs (nise, celebrex 200) in treatment of pyo-inflammatory diseases of the soft tissues for determination of the probability of the development of acute gastric and/or duodenal ulcers. Materials and methods. Treatment of 30 patients with abscessing hydradenitis was assessed using a randomized controlled study. All patients were divided into two groups, 15 persons each: the main and the comparison groups. In the main group, complex anti-inflammatory therapy included coxibs (celebrex 200), in the comparison group - nonsteroid anti-inflammatory drugs (nise). Results. In the comparison group, the results of fibrogastroduodenoscopy after the conducted therapy showed presence of gastric mucosa erosions in 60% of patients. In patients of the main group, no changes in gastric mucosa were observed. Conclusions. Coxibs applied as anti-inflammatory therapy in the treatment of pyo-inflammatory diseases of the soft tissues reduce risk for the development of acute gastric and/or duodenal ulcers of drug genesis.

Acute ulcer, fibrogastroduodenoscopy, coxibs, hydradenitis