CLINICOPATHOGENETIC PECULIARITIES AND PREVENTION OF TICK-BORNE BORRELIOSES

Aim. The aim of the study was to analyze the clinicopathogenetic peculiarities of tick-borne borrelioses (TBB) course in Perm Krai and their prevention. Materials and methods. During the period from 1991 to 2015, a complex clinicolaboratory and instrumental examination of 1878 patients with borrelioses was carried out at Regional Clinical Infectious Hospital of the city of Perm. Results. The disease is manifested in two forms: erythemal (77,5 %) and erythema-free (22,5 %). The organ pathology includes the damage of nervous and cardiovascular systems, locomotor system and liver. Reliable increase in the total peripheral resistance was detected while studying the hemodynamic structure. Decrease in tissue oxygenation, capillary-tissue oxygen diffusion, tissue metabolism and blood flow was revealed when determining the state of tissue gaseous metabolism. While studying the parameters of hemostasis, changes in the form of raised SFMC level, fall in Pt and APTT were found ( p < 0,05). Platelet serotonin neuromediator level analyzed in borrelioses patients indicated significant reduction in this index versus the control values. Conclusions. The peculiar feature of acute borreliosis course consists in the damage of different organs and systems that should be taken into consideration in diagnosis of this disease. New pathogenetic mechanisms in the form of structural and functional vascular changes, disturbed hemostasis in the form of development of latent syndrome of disseminated intravascular clotting were stated. Decrease in activity of cerebral serotoninergic structures in case of acute borreliosis course was established and need for correction of this status was shown. To prevent TBB development, it is necessary to carry out an antibacterial preventive course, which is of great efficiency, and results in a 10-12 fold reduction of morbidity.

Tick-borne bordelaises, pathogenesis, clinical picture, prevention