Disturbances of carbohydrate metabolism and postoperative complications after distal pancreatic resection
- Authors: Barykov V.N.1, Istomin A.G.2, Markina N.V.1, Tyulganova V.L.2
-
Affiliations:
- South-Ural State Medical University
- Chelyabinsk Regional Clinical Hospital
- Issue: Vol 37, No 3 (2020)
- Pages: 33-39
- Section: Original studies
- URL: https://journals.rcsi.science/PMJ/article/view/44249
- DOI: https://doi.org/10.17816/pmj37333-39
- ID: 44249
Cite item
Full Text
Abstract
Objective. To study the state of carbohydrate metabolism in patients after distal pancreatic resection and its effect on the development of postoperative complications.
Materials and methods. Over 10 years, 47 patients have been operated on with various tumors of the body/tail of the pancreas and complications of chronic pancreatitis. In 16 of them, concomitant diabetes mellitus was diagnosed before surgery, and in 31 patients, carbohydrate metabolism was normal.
Results. After surgery, from a group of patients with unchanged carbohydrate metabolism, 8 (25.8 %) developed diabetes mellitus. The following postoperative complications – pancreatic fistula, inflammatory infiltrates and "fluid leakages” in the abdominal cavity – occurred in 68 % of cases. Out of 24 patients with diabetes mellitus, complications were registered in 21 (87.5 %) and of 23 diabetes-free patients – in 11 (47.8 %).
Conclusions. The total risk for the development of the postoperative abdominal complications after the distal resection in patients with diabetes mellitus, diagnosed before and after the intervention, is 7.6 times higher than in patients without diabetes.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
V. N. Barykov
South-Ural State Medical University
Author for correspondence.
Email: barykov50@mail.ru
MD, PhD, Professor, Head of Department of Hospital Surgery
Russian Federation, ChelyabinskA. G. Istomin
Chelyabinsk Regional Clinical Hospital
Email: barykov50@mail.ru
surgeon, First Surgical Unit
Russian Federation, ChelyabinskN. V. Markina
South-Ural State Medical University
Email: barykov50@mail.ru
Candidate of Technical Sciences, Associate Professor, Head of Department of Mathematics, Medical Informatics and Statistics, Physics
Russian Federation, ChelyabinskV. L. Tyulganova
Chelyabinsk Regional Clinical Hospital
Email: barykov50@mail.ru
Candidate of Medical Sciences, Head of Endocrinological Unit
Russian Federation, ChelyabinskReferences
- Voskanjan S.Je., Najdenov E.V., Uteshev I.Ju., Artem'ev A.I., Udalov Ju.D., Zabelin M.V. Dependence of the direct results of corporocaudal pancreatic resection on the methods of formation and processing its stump. Vestnik hirurgii 2018, 177 (4): 23–27 (in Russian).
- Ejaz A., Sachs T., He J. et al. A comparison of open and minimally invasive surgery for hepatic and pancreatic resections using the Nationwide Inpatient Sample. Surgery 2014; 156: 538–547. doi: 10.1016/j.surg.2014.03.046.
- Justin V., Fingerhut A., Khatkov I., Uranues S. Laparoscopic pancreatic resection – a review. Trans Gastroenterol Hepatol 2016; 1: 36. doi: 10.21037/tgh.2016.04.02
- Kashincev A.A., Kohanenko A.Ju. The relationship between diabetes and pancreatic cancer. Sibirskij onkologicheskij zhurnal 2013; 4 (58): 36–39 (in Russian).
- Lebedeva A.N., Demidova V.S., Kriger A.N., Shevchenko T.V. The state of carbohydrate metabolism after pancreatoduodenal resections in patients with chronic pancreatitis. Hirurgija 2011; 3: 8–12 (in Russian).
- Lebedeva A.N., Kubyshkin V.N., Demidova V.S. Diabetes and Pancreatic Cancer. Hirurgija 2013; 4: 82–86 (in Russian).
- Lebedeva A.N. Surgical treatment of pancreatic diseases: metabolic consequences, diagnosis and perioperative management, prognosis: avtoref. dis. … doktora med. nauk. M. 2017; 52 (in Russian).
- Mehrabi A., Hafezi M., Arvin J. et al. A systematic review and meta-analysis of laparoscopic versus open distal pancreatectomy for benign and malignant lesions of the pancreas: its time to randomize. Surgery 2015; 157 (1): 45–55. doi: 10.1016/j.surg.2014.06.081
- Alikberzade A.V., Krylov N.N., Adzhun Z., Laftavi M.R., Shahbazov R.O., Zujkova K.S. The current state of the problem of allotransplantation of Langerhans cells (achievements and prospects). Hirurgija 2018; 11: 80–88 (in Russian).
- Hill N.R., Oliver N.S., Choudhary P., Levy J.C., Hindmarsh P., Matthews D.R. Normal Reference Range for Mean Tissue Glucose and Glycemic Variability Derived from Continuous Glucose Monitoring for Subjects Without Diabetes in Different Ethnic Groups. Diabetes Technol Ther 2011; 13 (9): 921–928. doi: 10.1089/dia.2010.0247
- Klimontov V.V., Mjakina N.E. Glycemic variability in diabetes mellitus: a tool for assessing the quality of glycemic control and the risk of complications. Saharnyj diabet 2014; 2: 76–82. doi: 10.14341/DM2014276-82 (in Russian).
- ServiceFj. Glucose variability. Diabetes 2013; 62 (5): 1398–1404. doi: 10.2337/db 12-1396.