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Post a Comment Chromosomal microarray analysis of ovum material in tubal pregnancy
- Authors: Olina A.A.1, Sadykova G.K.2
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Affiliations:
- Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- E.A.Vagner Perm State Medical University
- Issue: Vol 37, No 3 (2020)
- Pages: 26-32
- Section: Original studies
- URL: https://journals.rcsi.science/PMJ/article/view/44243
- DOI: https://doi.org/10.17816/pmj37326-32
- ID: 44243
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Abstract
Objective. To determine the significance of chromosomal aberrations in ectopic pregnancy. An ectopic pregnancy is a complication that occurs in approximately 1–2 % of all pregnancies and can cause morbidity and mortality in women of childbearing age. Identification of potential risk factors for the diagnosis of ectopic pregnancy remains an urgent, incompletely studied question.
Materials and methods. A descriptive exploratory study was conducted on the basis of the City Clinical Hospital named after M.A. Tverie, Perm. The objects of the study were 20 women with tubal pregnancy. All patients were admitted to the gynecological unit of the clinic with a diagnosis of “progressing tubal pregnancy”, for which tubotomy with laparoscopic access was performed that allowed to preserve the integrity of the material. Besides traditional histological study, in all cases a chromosome microarray analysis of the fetal egg was performed.
Results. In addition to routine histological study, in all cases of the analyzed group, a chromosome microarray analysis of the ovum material was carried out. It turned out that in one case, in a 28-year-old patient with a five-week tubal frozen pregnancy a complex chromosome imbalance was found: three copies of 1–6, 8–22 and X chromosomes and four copies of chromosome 7, molecular karyotype (according to ISCN 2016): arr (1–6. 8–22, X) x3, (7) x4.
Conclusions. Despite the fact that genetic breakdowns are uncontrollable factors and it is not possible to directly influence them, the search for possible mechanisms leading to them is promising.
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##article.viewOnOriginalSite##About the authors
A. A. Olina
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Author for correspondence.
Email: gulnara-sadykova@mail.ru
MD, PhD, Deputy Director for Development
Russian Federation, Saint PetersburgG. K. Sadykova
E.A.Vagner Perm State Medical University
Email: gulnara-sadykova@mail.ru
Candidate of Medical Sciences, Associate Professor of Department of Obstetrics and Gynecology №1
Russian Federation, PermReferences
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