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Post a Comment A CASE OF HEREDITARY THROMBOPHILIA AND WARFARIN SKIN NECROSIS
- Authors: Borodina EN1, Bachurina MA1
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Affiliations:
- Пермская государственная медицинская академия им. ак. Е. А. Вагнера, г. Пермь, Россия
- Issue: Vol 31, No 6 (2014)
- Pages: 115-121
- Section: Articles
- URL: https://journals.rcsi.science/PMJ/article/view/3448
- DOI: https://doi.org/10.17816/pmj316115-121
- ID: 3448
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Abstract
A clinical case of hereditary thrombophilia caused by mutation of blood coagulation factor V (Leidan mutation) is presented in the paper. The peculiar features of this case are: first - heterozygote mutation manifested at the age of 30, second - development of a rare side effect of indirect oral anticoagulant - warfarin - skin necrosis. Warfarin necroses occur in deficiency of C and S proteins. Combination of genetic defects in the system of hemostasis and pathology of gastrointestinal tract originated from patient’s childhood led to essential changes in pharmacodynamics and pharmacokinetics of indirect anticoagulant. This clinical example demonstrates need in introduction of moleculogenetic testing into clinical practice not only for diagnosis, but for choosing drugs, as well. Pharmacogenetic approach can be one of the keys to individualization of drug therapy.
About the authors
E N Borodina
Пермская государственная медицинская академия им. ак. Е. А. Вагнера, г. Пермь, Россия
Email: borodinalena@yandex.ru
кандидат медицинских наук, доцент кафедры факультетской терапии №1 с курсом физиотерапии ДПО
M A Bachurina
Пермская государственная медицинская академия им. ак. Е. А. Вагнера, г. Пермь, Россияординатор кафедры факультетской терапии №1 с курсом физиотерапии ДПО
References
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