LABORATORY CRITERIA FOR DIAGNOSIS OF EARLY HEALTH STATUS DISTURBANCES IN AGROINDUSTRIAL COMPLEX WORKERS

Aim. To determine the informative laboratory criteria for early revealing of disturbed health status in conditions of chronic aerogenic load, to estimate hemostasis indices regarding trend and intensity of correlations between the components. Materials and methods. The data of profound examination of 360 workers of large poultry complex in conditions of periodic medical examination were analyzed. Activity of hepatocyte cytolysis markers was determined, blood serum lipid spectrum was investigated, different components of immunity were assessed using levels I-II immunological tests. Group 1 consisted of 215 persons of main professions, group 2 – 145 additional professions. Results. The most frequently diagnosed diseases among poultry farm workers are the diseases of locomotor system (vertebrogenic cervicoischia-dorsalgia, osteochondroses, osteoarthroses). This pathology was detected in 68,8±0,22% of the examined patients of group 1 and 58,6±0,34% – group 2. Cardiovascular disorders are mostly presented by arterial hypertension – 23,7±0,2% in the group of main workers and 31,03±0,3%b – in group 2. When comparing prevalence of cardiovascular diseases and lipid profile disturbances in the workers of main professions it was established that hypercholesterinemia occurred more often than clinical manifestations of disease (53,0% and 38,1%, respectively). Aggregate of increased total cholesterol and glucose levels, excess body mass characterize development of metabolic syndrome in the examined patients. Taking into account the results of clinical investigation, diabetes mellitus and thyroid diseases are diagnosed only in 6,6% of the examined patients. Conclusion. Patients exposed to industrial factors were found to have significant disturbances of lipid and carbohydrate metabolism that proves presence of metabolic syndrome. Among workers of main professions, changes in immunoresponsiveness of the body are noted significantly more often.

Industrial poultry farming, biochemical indices, harmful effect of industrial factors